Journal article
Nonsyndromic Hearing Loss
Ear and hearing, Vol.24(4), pp.275-288
08/2003
DOI: 10.1097/01.AUD.0000079805.04016.03
PMID: 12923419
Abstract
The past decade has seen extremely rapid progress in the field of hereditary hearing loss. To date, 80 loci for nonsyndromic hearing loss have been mapped to the human genome. Furthermore, 30 genes have been identified. These genes belong to a wide variety of protein classesfrom myosins and other cytoskeletal proteins, over channel and gap junction components, to transcription factors, extracellular matrix proteins and genes with an unknown function. The identification of these genes has enabled geneticists to offer DNA diagnostic tests for some types of nonsyndromic hearing loss. Moreover, it holds the promise to significantly improve the molecular knowledge on the auditory and vestibular organs and on the pathological mechanisms leading to hearing loss. This opens perspectives for future therapeutic and/or preventive measures for hearing loss. This review attempts to give an overview of the current knowledge of the genes responsible for nonsyndromic hearing loss, their expression and functions in the cochlea.
Details
- Title: Subtitle
- Nonsyndromic Hearing Loss
- Creators
- Lut Van Laer - Department of Medical Genetics (L.V.L., K.C., G.V.C.), University of Antwerp, Antwerp, Belgium; and Molecular Otolaryngology Research Laboratories (R.J.H.S.), Department of Otolaryngology–Head and Neck Surgery, University of Iowa, Iowa City, IowaKim CrynsRichard SmithGuy Van Camp
- Resource Type
- Journal article
- Publication Details
- Ear and hearing, Vol.24(4), pp.275-288
- DOI
- 10.1097/01.AUD.0000079805.04016.03
- PMID
- 12923419
- NLM abbreviation
- Ear Hear
- ISSN
- 0196-0202
- eISSN
- 1538-4667
- Publisher
- Lippincott Williams & Wilkins, Inc
- Language
- English
- Date published
- 08/2003
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Molecular Physiology and Biophysics; Anatomy and Cell Biology; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Otolaryngology; Internal Medicine
- Record Identifier
- 9984007182902771
Metrics
9 Record Views