Journal article
Normal Caudate Glucose Metabolism in Persons at Risk for Huntington's Disease
Archives of neurology (Chicago), Vol.44(3), pp.254-257
03/01/1987
DOI: 10.1001/archneur.1987.00520150010010
PMID: 2950844
Abstract
• Glucose metabolism was examined by positron emission tomographic scanning with18F-2-fluoro-2-deoxy-d-glucose in 29 persons at risk for Huntington's disease (HD), 28 age-matched controls, nine patients with stage I, and eight patients with stage II symptomatic HD. Absolute caudate metabolic rates and normalized indexes of caudate metabolism for at-risk persons were normal compared with controls. No at-risk person had caudate indexes outside two SDs of the controls' mean. Caudate metabolism in the earliest HD cases was significantly reduced compared with controls and atrisk persons, but within the 99% confidence levels of both groups. Stage II patients had caudate measures that were significantly depressed compared with those of stage I HD patients. Measurement of caudate glucose hypometabolism is unlikely to be sufficiently sensitive to serve as a presymptomatic marker of heterozygote status, although it will provide a sensitive marker for progressive caudate dysfunction in HD.
Details
- Title: Subtitle
- Normal Caudate Glucose Metabolism in Persons at Risk for Huntington's Disease
- Creators
- Anne B YoungJohn B PenneySimon Starosta-RubinsteinDorene MarkelStanley BerentJill RothleyAnnette BetleyRichard Hichwa
- Resource Type
- Journal article
- Publication Details
- Archives of neurology (Chicago), Vol.44(3), pp.254-257
- DOI
- 10.1001/archneur.1987.00520150010010
- PMID
- 2950844
- NLM abbreviation
- Arch Neurol
- ISSN
- 0003-9942
- eISSN
- 1538-3687
- Publisher
- American Medical Association
- Language
- English
- Date published
- 03/01/1987
- Academic Unit
- Radiology; Research Administration; Physics and Astronomy; Radiation Oncology
- Record Identifier
- 9984213444602771
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