Normal brain irradiation during stereotactic brain implants using radioactive iodine-125

S K Jani; P W Hitchon; J C VanGilder; B C Wen

doi:10.1159/000100732

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Journal article

Normal brain irradiation during stereotactic brain implants using radioactive iodine-125

S K Jani, P W Hitchon, J C VanGilder and B C Wen

Applied neurophysiology, Vol.50(1-6), pp.310-313

1987

DOI: 10.1159/000100732

PMID: 3329869

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Abstract

Stereotactic interstitial brain implants deliver locally high radiation doses to treat malignant gliomas. Dose to the surrounding normal brain from an 125I implant has been compared with the dose from an external irradiation technique. Results show that an implant offers a higher dose gradient around the tumor and hence a lower dose to the normal brain. Moreover, some irregular-shaped tumors, while ideal for a stereotactic implant, may be very difficult to treat with external beams without delivering a significant radiation dose to the normal brain. An implant seems to be dosimetrically superior to external irradiation for delivering large tumor doses.

Radiotherapy Dosage

Iodine Radioisotopes - therapeutic use

Brachytherapy

Brain Neoplasms - radiotherapy

Humans

Stereotaxic Techniques

Details

Title: Subtitle: Normal brain irradiation during stereotactic brain implants using radioactive iodine-125
Creators: S K Jani - Division of Radiation Oncology, University of Iowa Hospitals and Clinics, Iowa City
P W Hitchon
J C VanGilder
B C Wen
Resource Type: Journal article
Publication Details: Applied neurophysiology, Vol.50(1-6), pp.310-313
DOI: 10.1159/000100732
PMID: 3329869
NLM abbreviation: Appl Neurophysiol
ISSN: 0302-2773
Publisher: Switzerland
Language: English
Date published: 1987
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Neurosurgery
Record Identifier: 9984040586102771

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