Normal childhood developmental patterns in skull bone marrow by MR imaging

T M Simonson; S C Kao

doi:10.1007/BF02015347

Back

Normal childhood developmental patterns in skull bone marrow by MR imaging

Journal article

Peer reviewed

Normal childhood developmental patterns in skull bone marrow by MR imaging

T M Simonson and S C Kao

Pediatric radiology, Vol.22(8), pp.556-559

1992

DOI: 10.1007/BF02015347

PMID: 1491927

View Online

Abstract

To establish the normal developmental pattern of skull bone marrow in children by MR imaging, sagittal T1-weighted MR skull images of 324 normal children (newborn to 18 years) were reviewed. Bone marrow intensity was assigned four gradations as compared with that of muscle and fat on the same image. Bone marrow became isointense with fat (yellow marrow) at a mean age +/- S.E.M. (in years) of 8.5 +/- 0.24 in sphenoid, 9.1 +/- 0.29 in mandible, 9.3 +/- 0.28 in hard palate, 9.7 +/- 0.26 in frontal, 11.0 +/- 0.26 in squamous occiput, 11.5 +/- 0.28 in parietal, and 11.9 +/- 0.24 in basiocciput. There is a strong correlation between age and marrow intensity by Spearman analysis (p < 0.001): hard palate 0.64, mandible 0.61, parietal 0.42, sphenoid 0.70, cervical spine 0.50, basi-occiput 0.58 and occiput 0.52. Two consistent overall patterns of red-yellow marrow conversion were observed. Bone marrow became isointense with fat prior to pneumatization of the paranasal sinuses. Marrow conversion in the bones of the face occurred before those of the calvarium in a specific pattern. There was no significant sex difference in the pattern or rate of marrow conversion. These normative data are necessary to evaluate the immature skull by MR imaging in disease states.

Bone Marrow - growth & development

Humans

Child, Preschool

Infant

Male

Reference Values

Magnetic Resonance Imaging

Bone Marrow - anatomy & histology

Skull - anatomy & histology

Adolescent

Female

Child

Infant, Newborn

Details

Title: Subtitle: Normal childhood developmental patterns in skull bone marrow by MR imaging
Creators: T M Simonson - Department of Radiology, University of Iowa College of Medicine, Iowa City 52242
S C Kao
Resource Type: Journal article
Publication Details: Pediatric radiology, Vol.22(8), pp.556-559
Publisher: Germany
DOI: 10.1007/BF02015347
PMID: 1491927
ISSN: 0301-0449
eISSN: 1432-1998
Language: English
Date published: 1992
Academic Unit: Radiology; Stead Family Department of Pediatrics
Record Identifier: 9984051886202771

Metrics

38 Record Views

27 Times Cited - Web of Science