Journal article
Normal left ventricular diastolic compliance after regression of hypertrophy
Journal of cardiovascular pharmacology, Vol.23(3), pp.349-357
1994
PMID: 7515976
Abstract
We wished to determine whether (a) left ventricular (LV) diastolic chamber compliance and tissue elastic modulus were decreased with hypertrophy and improved after reversal of hypertension and regression of hypertrophy and whether collagen concentration was a major determinant of LV chamber compliance during hypertrophy or aging. Spontaneously hypertensive rats (SHR) and Wistar-Kyoto rats (WKY), aged 8 months at time of study, were used for the hypertension-regression experiments. The aging study was based on 14- and 24-month-old Fischer-344 rats. LV chamber compliance was measured in isolated perfused hearts arrested in diastole. Length-tension curves (tissue elastic modulus) were obtained from ventricular strips, and hydroxyproline assays were used to estimate LV collagen content. Captopril and hydrochlorothizide were given for an 8-week period to both normotensive and hypertensive rats. Treatment normalized arterial pressure and caused regression of LV hypertrophy in SHR. LV diastolic compliance was less (pressure-volume curve steeper) in SHR than in WKY, but stiffness was similar in the two groups, as indicated by similar slopes when volume was adjusted for heart mass. Treatment significantly decreased ventricular stiffness in both SHR and WKY. Length-tension curves were almost identical in SHR and WKY, but treated SHR demonstrated less tension per given length. These changes occurred although collagen did not decrease in parallel to the decrease in LV mass. Aging was associated with 66 and 60% increases in collagen content and concentration, respectively, but did not alter LV chamber compliance significantly.
Details
- Title: Subtitle
- Normal left ventricular diastolic compliance after regression of hypertrophy
- Creators
- J. A SCHRAEGER - Univ. Iowa, cardiovascular cent., dep. anatomy, Iowa City IA 52242, United StatesC. A CANBY - Univ. Iowa, cardiovascular cent., dep. anatomy, Iowa City IA 52242, United StatesB. J RONGISH - Univ. Iowa, cardiovascular cent., dep. anatomy, Iowa City IA 52242, United StatesM KAWAI - Univ. Iowa, cardiovascular cent., dep. anatomy, Iowa City IA 52242, United StatesR. J TOMANEK - Univ. Iowa, cardiovascular cent., dep. anatomy, Iowa City IA 52242, United States
- Resource Type
- Journal article
- Publication Details
- Journal of cardiovascular pharmacology, Vol.23(3), pp.349-357
- Publisher
- Lippincott; Philadelphia, PA; Hagerstown, MD
- PMID
- 7515976
- ISSN
- 0160-2446
- eISSN
- 1533-4023
- Language
- English
- Date published
- 1994
- Academic Unit
- Anatomy and Cell Biology; Internal Medicine
- Record Identifier
- 9984025332902771
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