Journal article
Normal neuroanatomical variation due to age: the major lobes and a parcellation of the temporal region
Neurobiology of aging, Vol.26(9), pp.1245-60; discussion 1279-82
10/01/2005
DOI: 10.1016/j.neurobiolaging.2005.05.023
PMID: 16046030
Abstract
We used high-resolution MRI to investigate gray and white matter aging in the major lobes of the cerebrum (frontal, parietal, temporal, occipital) and the major sectors of the temporal lobe (temporal pole, superior temporal gyrus, infero-temporal region, parahippocampal gyrus, amygdala, hippocampus). Subjects included 87 adults between the ages of 22 and 88 years. Regions of interest were hand-traced on contiguous 1.5mm coronal slices. For the cerebrum in general, gray matter decreased linearly with age, resulting in a decline of about 9.1-9.8% between the ages of 30 and 70 years, and a decline of 11.3-12.3% by the age of 80. In contrast, white matter volume increased until the mid-50s, after which it declined at an accelerated rate. At 70 years, white matter volume was only 5.6-6.4% less than at 30 years, but by age 80, a cubic regression model predicted that the decrease would be 21.6-25.0%. Multivariate analyses indicate that the frontal gray matter was most strongly associated with age, while occipital gray and white matter were least associated. Reduction in volume in the hippocampus was best modeled by a cubic regression model rather than a linear model. No sex differences in aging were found for any regions of interest.
Details
- Title: Subtitle
- Normal neuroanatomical variation due to age: the major lobes and a parcellation of the temporal region
- Creators
- John S Allen - University of IowaJoel Bruss - University of Iowa Hospitals and ClinicsC Kice BrownHanna Damasio - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Neurobiology of aging, Vol.26(9), pp.1245-60; discussion 1279-82
- DOI
- 10.1016/j.neurobiolaging.2005.05.023
- PMID
- 16046030
- ISSN
- 0197-4580
- eISSN
- 1558-1497
- Language
- English
- Date published
- 10/01/2005
- Academic Unit
- Stead Family Department of Pediatrics
- Record Identifier
- 9984622051202771
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