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Normalization of fasting hyperglucagonemia and excessive glucagon responses to intravenous arginine in human diabetes mellitus by prolonged infusion of insulin
Journal article   Peer reviewed

Normalization of fasting hyperglucagonemia and excessive glucagon responses to intravenous arginine in human diabetes mellitus by prolonged infusion of insulin

J E Gerich, E Tsalikian, M Lorenzi, V Schneider, N V Bohannon, G Gustafson and J H Karam
The journal of clinical endocrinology and metabolism, Vol.41(6), pp.1178-1180
12/1975
DOI: 10.1210/jcem-41-6-1178
PMID: 1206104

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Abstract

Infusion of insulin (1 U/hr) for 14 hr suppressed basal glucagon levels and normalized previously excessive glucagon responses to arginine in juvenile-onset, insulin-dependent diabetic subjects, indicating that abnormal pancreatic alpha-cell function in human juvenile-onset diabetes mellitus may be a consequence of insulin lack.
Fasting Arginine Time Factors Humans Diabetes Mellitus - drug therapy Adult Female Male Glucagon - secretion Glucagon - blood Insulin - therapeutic use

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