Journal article
Nosocomial bloodstream infections due to Acinetobacter baumannii, Acinetobacter pittii and Acinetobacter nosocomialis in the United States
Journal of Infection, Vol.64(3), pp.282-290
03/2012
DOI: 10.1016/j.jinf.2011.12.008
PMID: 22209744
Abstract
To compare the clinical features and antimicrobial susceptibilities of the clinically most important Acinetobacter species Acinetobacter baumannii, Acinetobacter pittii (formerly Acinetobacter genomic species 3) and Acinetobacter nosocomialis (formerly Acinetobacter genomic species 13TU). 295 Acinetobacter isolates collected prospectively from patients with bloodstream infections (BSI) in 52 US hospitals were identified to species level. Clinical and microbiological features were compared between species. A. baumannii (63%) was the most prevalent species, followed by A. nosocomialis (21%), and A. pittii (8%). Intravascular catheters (15.3%) and the respiratory tract (12.9%) were the most frequent sources of BSI. A higher overall mortality was observed in patients with A. baumannii BSI than in patients with BSI caused by A. nosocomialis and A. pittii (36.9% vs. 16.4% and 13.0%, resp., p < 0.001). The most active antimicrobial agents as determined by broth microdilution were tigecycline (99.6% of isolates susceptible), colistin (99.3%), amikacin (98.5%), and imipenem (95.2%). 27 isolates (10.0%) were multi-drug resistant, all but one of these were A. baumannii. About one third of Acinetobacter BSI in our study were caused by A. nosocomialis or A. pittii. Patients with A. baumannii BSI had a less favorable outcome.
Details
- Title: Subtitle
- Nosocomial bloodstream infections due to Acinetobacter baumannii, Acinetobacter pittii and Acinetobacter nosocomialis in the United States
- Creators
- Hilmar Wisplinghoff - Institute for Medical Microbiology, Immunology and Hygiene, University of Cologne, Goldenfelsstr. 19-21, 50935 Cologne, GermanyTobias Paulus - Institute for Medical Microbiology, Immunology and Hygiene, University of Cologne, Goldenfelsstr. 19-21, 50935 Cologne, GermanyMarianne Lugenheim - Institute for Medical Microbiology, Immunology and Hygiene, University of Cologne, Goldenfelsstr. 19-21, 50935 Cologne, GermanyDanuta Stefanik - Institute for Medical Microbiology, Immunology and Hygiene, University of Cologne, Goldenfelsstr. 19-21, 50935 Cologne, GermanyPaul G Higgins - Institute for Medical Microbiology, Immunology and Hygiene, University of Cologne, Goldenfelsstr. 19-21, 50935 Cologne, GermanyMichael B Edmond - Division of Infectious Diseases, Department of Internal Medicine, Virginia Commonwealth University, Richmond, VA 23298, USARichard P Wenzel - Division of Infectious Diseases, Department of Internal Medicine, Virginia Commonwealth University, Richmond, VA 23298, USAHarald Seifert - Institute for Medical Microbiology, Immunology and Hygiene, University of Cologne, Goldenfelsstr. 19-21, 50935 Cologne, Germany
- Resource Type
- Journal article
- Publication Details
- Journal of Infection, Vol.64(3), pp.282-290
- Publisher
- Elsevier Ltd
- DOI
- 10.1016/j.jinf.2011.12.008
- PMID
- 22209744
- ISSN
- 0163-4453
- eISSN
- 1532-2742
- Language
- English
- Date published
- 03/2012
- Academic Unit
- Infectious Diseases; Internal Medicine
- Record Identifier
- 9983905645602771
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