Nosocomial bloodstream infections in United States hospitals: a three-year analysis

Michael B Edmond; Sarah E Wallace; Donna K McClish; Michael A Pfaller; Ronald N Jones; Richard P Wenzel

doi:10.1086/520192

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Nosocomial bloodstream infections in United States hospitals: a three-year analysis

Journal article

Open access

Peer reviewed

Nosocomial bloodstream infections in United States hospitals: a three-year analysis

Michael B Edmond, Sarah E Wallace, Donna K McClish, Michael A Pfaller, Ronald N Jones and Richard P Wenzel

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, Vol.29(2), pp.239-244

08/1999

DOI: 10.1086/520192

PMID: 10476719

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Abstract

Nosocomial bloodstream infections are important causes of morbidity and mortality. In this study, concurrent surveillance for nosocomial bloodstream infections at 49 hospitals over a 3-year period detected >10,000 infections. Gram-positive organisms accounted for 64% of cases, gram-negative organisms accounted for 27%, and 8% were caused by fungi. The most common organisms were coagulase-negative staphylococci (32%), Staphylococcus aureus (16%), and enterococci (11%). Enterobacter, Serratia, coagulase-negative staphylococci, and Candida were more likely to cause infections in patients in critical care units. In patients with neutropenia, viridans streptococci were significantly more common. Coagulase-negative staphylococci were the most common pathogens on all clinical services except obstetrics, where Escherichia coli was most common. Methicillin resistance was detected in 29% of S. aureus isolates and 80% of coagulase-negative staphylococci. Vancomycin resistance in enterococci was species-dependent--3% of Enterococcus faecalis strains and 50% of Enterococcus faecium isolates displayed resistance. These data may allow clinicians to better target empirical therapy for hospital-acquired cases of bacteremia.

United States

Staphylococcus - classification

Humans

Fungemia - blood

Fungemia - microbiology

Candida - isolation & purification

Gram-Negative Bacteria - isolation & purification

Bacteremia - microbiology

Candida - classification

Hospitals

Gram-Positive Bacteria - classification

Staphylococcus - isolation & purification

Cross Infection - microbiology

Enterococcus - isolation & purification

Bacteremia - blood

Gram-Positive Bacteria - isolation & purification

Cross Infection - blood

Enterococcus - classification

Gram-Negative Bacteria - classification

Neutropenia

Details

Title: Subtitle: Nosocomial bloodstream infections in United States hospitals: a three-year analysis
Creators: Michael B Edmond - Department of Internal Medicine, Virginia Commonwealth University School of Medicine, Richmond 23298-0663, USA
Sarah E Wallace
Donna K McClish
Michael A Pfaller
Ronald N Jones
Richard P Wenzel
Resource Type: Journal article
Publication Details: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, Vol.29(2), pp.239-244
Publisher: United States
DOI: 10.1086/520192
PMID: 10476719
ISSN: 1058-4838
eISSN: 1537-6591
Language: English
Date published: 08/1999
Academic Unit: Epidemiology; Pathology; Internal Medicine
Record Identifier: 9983905521302771

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