Nosocomial bloodstream infections in pediatric patients in United States hospitals: epidemiology, clinical features and susceptibilities

Hilmar Wisplinghoff; Harald Seifert; Sandra M Tallent; Tammy Bischoff; Richard P Wenzel; Michael B Edmond

doi:10.1097/01.inf.0000078159.53132.40

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Nosocomial bloodstream infections in pediatric patients in United States hospitals: epidemiology, clinical features and susceptibilities

Journal article

Peer reviewed

Nosocomial bloodstream infections in pediatric patients in United States hospitals: epidemiology, clinical features and susceptibilities

Hilmar Wisplinghoff, Harald Seifert, Sandra M Tallent, Tammy Bischoff, Richard P Wenzel and Michael B Edmond

The Pediatric infectious disease journal, Vol.22(8), pp.686-691

08/2003

DOI: 10.1097/01.inf.0000078159.53132.40

PMID: 12913767

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Abstract

We identified the predominant pathogens and antimicrobial susceptibilities of nosocomial bloodstream isolates in pediatric patients in the US Prospective surveillance for nosocomial bloodstream infections at 49 hospitals during a 6-year period [Surveillance and Control of Pathogens of Epidemiologic Importance (SCOPE)] detected 22 609 bloodstream infections, of which 3432 occurred in patients < or =16 years of age. Gram-positive organisms accounted for 65% of cases, Gram-negative organisms accounted for 24% of cases and 11% were caused by fungi. The overall crude mortality was 14% (475 of 3432) but notably higher for infections caused by Candida spp. and Pseudomonas aeruginosa, 20 and 29%, respectively. The most common organisms were coagulase-negative staphylococci (43%), enterococci, Staphylococcus aureus and Candida spp. (each, 9%). The mean interval between admission and infection averaged 21 days for coagulase-negative staphylococci, 25 days for S. aureus and Candida spp., 32 days for Klebsiella spp. and 34 days for Enterococcus spp. The proportion of methicillin-resistant S. aureus increased from 10% in 1995 to 29% in 2001. Vancomycin-resistance was seen in 1% of Enterococcus faecalis and in 11% of Enterococcus faecium isolates. Nosocomial BSI occurred predominantly in very young and/or critically ill children. Gram-positive pathogens predominated across all ages, and increasing antimicrobial resistance was observed in pediatric patients.

United States - epidemiology

Age Distribution

Prospective Studies

Gram-Positive Bacteria - drug effects

Humans

Child, Preschool

Drug Resistance, Bacterial

Infant

Male

Gram-Negative Bacteria - isolation & purification

Incidence

Bacteremia - microbiology

Microbial Sensitivity Tests

Multicenter Studies as Topic

Female

Child

Cross Infection - epidemiology

Severity of Illness Index

Risk Factors

Bacteremia - drug therapy

Survival Rate

Fungemia - microbiology

Cross Infection - drug therapy

Gram-Negative Bacteria - drug effects

Hospitals

Cross Infection - microbiology

Gram-Positive Bacteria - isolation & purification

Sex Distribution

Bacteremia - epidemiology

Anti-Bacterial Agents - pharmacology

Blood-Borne Pathogens - isolation & purification

Fungemia - epidemiology

Cohort Studies

Details

Title: Subtitle: Nosocomial bloodstream infections in pediatric patients in United States hospitals: epidemiology, clinical features and susceptibilities
Creators: Hilmar Wisplinghoff - Institute for Medical Microbiology, Immunology and Hygiene, University of Cologne, Germany
Harald Seifert
Sandra M Tallent
Tammy Bischoff
Richard P Wenzel
Michael B Edmond
Resource Type: Journal article
Publication Details: The Pediatric infectious disease journal, Vol.22(8), pp.686-691
Publisher: United States
DOI: 10.1097/01.inf.0000078159.53132.40
PMID: 12913767
ISSN: 0891-3668
eISSN: 1532-0987
Language: English
Date published: 08/2003
Academic Unit: Infectious Diseases; Internal Medicine
Record Identifier: 9983905527802771

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