Nosocomial outbreak of tuberculosis in a renal transplant unit: application of a new technique for restriction fragment length polymorphism analysis of Mycobacterium tuberculosis isolates

John A Jereb; Dale R Burwen; Samuel W Dooley; Walter H Haas; Jack T Crawford; Lawrence J Geiter; Michael B Edmund; John N Dowling; Ron Shapiro; A William Pasculle; Sandra L Shanahan; William R Jarvis

doi:10.1093/infdis/168.5.1219

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Nosocomial outbreak of tuberculosis in a renal transplant unit: application of a new technique for restriction fragment length polymorphism analysis of Mycobacterium tuberculosis isolates

Journal article

Peer reviewed

Nosocomial outbreak of tuberculosis in a renal transplant unit: application of a new technique for restriction fragment length polymorphism analysis of Mycobacterium tuberculosis isolates

John A Jereb, Dale R Burwen, Samuel W Dooley, Walter H Haas, Jack T Crawford, Lawrence J Geiter, Michael B Edmund, John N Dowling, Ron Shapiro, A William Pasculle, …

The Journal of infectious diseases, Vol.168(5), pp.1219-1224

11/1993

DOI: 10.1093/infdis/168.5.1219

PMID: 7901287

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Abstract

From January 1990 through February 1991, tuberculosis (TB) developed in 10 renal transplant (RT) patients at one hospital; 5 patients died. Possible nosocomial transmission was investigated. Mycobacterium tuberculosis isolates were compared by restriction fragment length polymorphism (RFLP) by a polymerase chain reaction method. The source case occurred in an RT patient (source) who had posttransplant exposure to TB at another hospital. The source patient was rehospitalized on the RT unit; diagnosis of TB and thus isolation precautions were delayed. Epidemiologic and RFLP analysis showed transmission from the source to 5 RT patients and 1 human immunodeficiency virus-infected patient. M. tuberculosis isolates from 4 RT patients had other RFLP patterns. The median incubation period for TB in RT patients was 7.5 weeks (range, 5-11). Bronchoscopy and intubation of the source patient and inadequate ventilation on the RT unit possibly increased transmission. Early detection of TB and effective isolation are essential to prevent nosocomial transmission.

Tuberculosis - epidemiology

Mycobacterium tuberculosis - classification

Humans

Middle Aged

Risk Factors

Male

Mycobacterium tuberculosis - isolation & purification

Contact Tracing

Polymorphism, Restriction Fragment Length

Disease Outbreaks

Adult

Female

Aged

Pennsylvania - epidemiology

Cross Infection - epidemiology

Kidney Transplantation - adverse effects

Details

Title: Subtitle: Nosocomial outbreak of tuberculosis in a renal transplant unit: application of a new technique for restriction fragment length polymorphism analysis of Mycobacterium tuberculosis isolates
Creators: John A Jereb - Division of Tuberculosis Elimination, Centers for Disease Control and Prevention, Atlanta, GA 30333
Dale R Burwen
Samuel W Dooley
Walter H Haas
Jack T Crawford
Lawrence J Geiter
Michael B Edmund
John N Dowling
Ron Shapiro
A William Pasculle
Sandra L Shanahan
William R Jarvis - University of California, Los Angeles
Resource Type: Journal article
Publication Details: The Journal of infectious diseases, Vol.168(5), pp.1219-1224
Publisher: United States
DOI: 10.1093/infdis/168.5.1219
PMID: 7901287
ISSN: 0022-1899
eISSN: 1537-6613
Language: English
Date published: 11/1993
Academic Unit: Infectious Diseases; Internal Medicine
Record Identifier: 9983905520202771

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