Journal article
Not your usual tRNA synthetase: HWARS serves as an enterovirus entry factor
The Journal of clinical investigation, Vol.128(11), pp.4767-4769
11/01/2018
DOI: 10.1172/JCI124582
PMCID: PMC6205376
PMID: 30320601
Abstract
Enteroviruses, including subtype EV-A71, infect the brain, liver, heart, and other organs, causing a myriad of human diseases. This spectrum of disease is thought to be due, in part, to differential binding to host cells, and additional knowledge of enterovirus cell entry is essential for therapeutic development. In this issue of the JCI, Yeung et al. provide evidence of a novel EV-A71 entry factor, a host-produced tryptophan tRNA synthetase (hWARS), that facilitates entry of multiple subtypes of enteroviruses. hWARS is a cytoplasmic enzyme that is essential for translation but also upregulated and secreted during inflammatory processes. The results of this study support the notion of secreted hWARS as an unconventional virus entry factor that raises interesting questions about mechanisms by which inflammation and a tRNA synthetase facilitate viral pathogenesis.
Details
- Title: Subtitle
- Not your usual tRNA synthetase: HWARS serves as an enterovirus entry factor
- Creators
- Stanley Perlman - University of Iowa, Stead Family Department of PediatricsTom Gallagher
- Resource Type
- Journal article
- Publication Details
- The Journal of clinical investigation, Vol.128(11), pp.4767-4769
- DOI
- 10.1172/JCI124582
- PMID
- 30320601
- PMCID
- PMC6205376
- NLM abbreviation
- J Clin Invest
- ISSN
- 0021-9738
- eISSN
- 1558-8238
- Publisher
- American Society for Clinical Investigation
- Language
- English
- Date published
- 11/01/2018
- Academic Unit
- Microbiology and Immunology; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Infectious Disease (Pediatrics)
- Record Identifier
- 9983782097702771
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