Journal article
Novel Aspects of Oxidative Stress in Cardiovascular Diseases
Circulation journal : official journal of the Japanese Circulation Society, Vol.73(2), pp.201-207
2009
DOI: 10.1253/circj.CJ-08-1082
PMCID: PMC2860751
PMID: 19110503
Abstract
Oxygen radicals, and other reactive oxygen species, may play an important role in the pathophysiology of atherosclerosis, stroke, and other cardiovascular diseases. Mechanisms that account for oxidative stress in different cardiovascular diseases are diverse; for example, increases in activity of NAD(P)H oxidase, "uncoupling" of nitric oxide synthase, and maladaptive changes in expression of antioxidants can all contribute to increases in oxidative stress. Very different patterns of pro-and antioxidant mechanisms that contribute to increases in oxygen radicals in atherosclerotic plaques, hemorrhagic strokes, and aortic valve stenosis have been observed. A disappointment, in relation to the hypothesis that oxygen radicals contribute to cardiovascular risk, is that many studies indicate that antioxidant vitamins fail to reduce the risk of cardiovascular disease. Better understanding of mechanisms that lead to increases in oxidative stress in different cardiovascular diseases may lead to more effective antioxidant prevention or treatment of diseases. (Circ J 2009; 73: 201 - 207)
Details
- Title: Subtitle
- Novel Aspects of Oxidative Stress in Cardiovascular Diseases
- Creators
- Donald D Heistad - Departments of Internal Medicine and Pharmacology, University of Iowa Carver College of MedicineYoshinobu Wakisaka - Departments of Internal Medicine and Pharmacology, University of Iowa Carver College of MedicineJordan Miller - Departments of Internal Medicine and Pharmacology, University of Iowa Carver College of MedicineYi Chu - Departments of Internal Medicine and Pharmacology, University of Iowa Carver College of MedicineRicardo Pena-Silva - Departments of Internal Medicine and Pharmacology, University of Iowa Carver College of Medicine
- Resource Type
- Journal article
- Publication Details
- Circulation journal : official journal of the Japanese Circulation Society, Vol.73(2), pp.201-207
- Publisher
- 一般社団法人 日本循環器学会
- DOI
- 10.1253/circj.CJ-08-1082
- PMID
- 19110503
- PMCID
- PMC2860751
- ISSN
- 1346-9843
- eISSN
- 1347-4820
- Language
- English
- Date published
- 2009
- Academic Unit
- Cardiovascular Medicine; Neuroscience and Pharmacology; Neurosurgery; Internal Medicine
- Record Identifier
- 9984040371502771
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