Journal article
Novel Honeycomb Nanoclay Frameworks With Hemostatic and Antibacterial Properties
Journal of biomedical materials research. Part B, Applied biomaterials, Vol.112(9), p.e35477
09/2024
DOI: 10.1002/jbm.b.35477
Appears in UI Libraries Support Open Access
Abstract
Our laboratory recently developed a new class of high surface area, honeycomb Nanoclay Microsphere Framework absorbents (NMFs) that prompt rapid hemostasis. In the present work, we propose a novel approach to develop antibacterial Topical Hemostatic Agents (THAs) by anchoring silver nanoparticles (AgNPs) onto NMFs. This combination was obtained by a chemical co‐reduction approach, followed by freeze‐processing, and was shown to ensure stability and on‐site delivery of AgNPs, without altering the hemostatic properties of NMFs. Silver‐loaded NMFs showed no change in their unique architecture and led to a 55% increase in clot strength, compared to standard control plasma or commercially available THA, and a significant decrease in mean fibrin fiber diameter. Silver nanoparticles were successfully released when solubilized and prevented the growth of both Pseudomonas aeruginosa and Staphylococcus aureus at concentrations of 22 and 30 ppm of silver released, respectively. Overall, cell mortality was between 9.1 ± 5.1% and 6.3 ± 3.2%, depending on AgNP concentration, confirming a low cytotoxicity. Silver‐loaded nanoclay microsphere frameworks appear to constitute promising candidates as topical hemostatic agents for secondary management of hemostasis when infection control is needed.
Details
- Title: Subtitle
- Novel Honeycomb Nanoclay Frameworks With Hemostatic and Antibacterial Properties
- Creators
- Mélyssa Cambronel - Université Clermont AuvergneKan Wongkamhaeng - Division of Prosthodontics, Faculty of Dentistry Thammasat University Khlong Luang ThailandChristelle Blavignac - Centre Imagerie Cellulaire Santé, UCA PARTNER, UFR de Médecine Clermont‐Ferrand FranceChristiane Forestier - Université Clermont AuvergneJean‐Marie Nedelec - Université Clermont AuvergneIsabelle Denry - University of Iowa, Prosthodontics
- Resource Type
- Journal article
- Publication Details
- Journal of biomedical materials research. Part B, Applied biomaterials, Vol.112(9), p.e35477
- Publisher
- Wiley
- DOI
- 10.1002/jbm.b.35477
- ISSN
- 1552-4973
- eISSN
- 1552-4981
- Grant note
This work was supported by National Institute of Dental and Craniofacial Research.
- Language
- English
- Date published
- 09/2024
- Academic Unit
- Prosthodontics
- Record Identifier
- 9984701158302771
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