Novel Member of the CD209 (DC-SIGN) Gene Family in Primates

Arman A Bashirova; Li Wu; Jie Cheng; Thomas D Martin; Maureen P Martin; Raoul E Benveniste; Jeffrey D Lifson; Vineet N KewalRamani; Austin Hughes; Mary Carrington

doi:10.1128/JVI.77.1.217-227.2003

Back

Novel Member of the CD209 (DC-SIGN) Gene Family in Primates

Journal article

Open access

Peer reviewed

Novel Member of the CD209 (DC-SIGN) Gene Family in Primates

Arman A Bashirova, Li Wu, Jie Cheng, Thomas D Martin, Maureen P Martin, Raoul E Benveniste, Jeffrey D Lifson, Vineet N KewalRamani, Austin Hughes and Mary Carrington

Journal of virology, Vol.77(1), pp.217-227

01/2003

DOI: 10.1128/JVI.77.1.217-227.2003

PMCID: PMC140574

PMID: 12477827

Files and links (1)

url

https://doi.org/10.1128/JVI.77.1.217-227.2003View

Published (Version of record) Open Access

Abstract

Two CD209 family genes identified in humans, CD209 ( DC-SIGN ) and CD209L ( DC-SIGNR / L-SIGN ), encode C-type lectins that serve as adhesion receptors for ICAM-2 and ICAM-3 and participate in the transmission of human and simian immunodeficiency viruses (HIV and SIV, respectively) to target cells in vitro. Here we characterize the CD209 gene family in nonhuman primates and show that recent evolutionary alterations have occurred in this family across primate species. All of the primate species tested, specifically, Old World monkeys (OWM) and apes, have orthologues of human CD209 . In contrast, CD209L is missing in OWM but present in apes. A third family member, that we have named CD209L2 , was cloned from rhesus monkey cDNA and subsequently identified in OWM and apes but not in humans. Rhesus CD209L2 mRNA was prominently expressed in the liver and axillary lymph nodes, although preliminary data suggest that levels of expression may vary among individuals. Despite a high level of sequence similarity to both human and rhesus CD209, rhesus CD209L2 was substantially less effective at binding ICAM-3 and poorly transmitted HIV type 1 and SIV to target cells relative to CD209. Our data suggest that the CD209 gene family has undergone recent evolutionary processes involving duplications and deletions, the latter of which may be tolerated because of potentially redundant functional activities of the molecules encoded by these genes.

Virus-Cell Interactions

Details

Title: Subtitle: Novel Member of the CD209 (DC-SIGN) Gene Family in Primates
Creators: Arman A Bashirova - Department of Biological Sciences, University of South Carolina, Columbia, South Carolina 29208
Li Wu - Department of Biological Sciences, University of South Carolina, Columbia, South Carolina 29208
Jie Cheng - Department of Biological Sciences, University of South Carolina, Columbia, South Carolina 29208
Thomas D Martin - Department of Biological Sciences, University of South Carolina, Columbia, South Carolina 29208
Maureen P Martin - Department of Biological Sciences, University of South Carolina, Columbia, South Carolina 29208
Raoul E Benveniste - Department of Biological Sciences, University of South Carolina, Columbia, South Carolina 29208
Jeffrey D Lifson - Department of Biological Sciences, University of South Carolina, Columbia, South Carolina 29208
Vineet N KewalRamani - Department of Biological Sciences, University of South Carolina, Columbia, South Carolina 29208
Austin Hughes - Department of Biological Sciences, University of South Carolina, Columbia, South Carolina 29208
Mary Carrington - Department of Biological Sciences, University of South Carolina, Columbia, South Carolina 29208
Resource Type: Journal article
Publication Details: Journal of virology, Vol.77(1), pp.217-227
DOI: 10.1128/JVI.77.1.217-227.2003
PMID: 12477827
PMCID: PMC140574
NLM abbreviation: J Virol
ISSN: 0022-538X
eISSN: 1098-5514
Publisher: American Society for Microbiology
Language: English
Date published: 01/2003
Academic Unit: Microbiology and Immunology
Record Identifier: 9984001116402771

Metrics

35 Record Views

45 Times Cited - Web of Science