Novel Mouse Model of Murine Cytomegalovirus-Induced Adaptive NK Cells

Isaac J Jensen; Matthew D Martin; Sandeep K Tripathy; Vladimir P Badovinac

doi:10.4049/immunohorizons.2100113

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Novel Mouse Model of Murine Cytomegalovirus-Induced Adaptive NK Cells

Journal article

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Novel Mouse Model of Murine Cytomegalovirus-Induced Adaptive NK Cells

Isaac J Jensen, Matthew D Martin, Sandeep K Tripathy and Vladimir P Badovinac

ImmunoHorizons, Vol.6(1), pp.8-15

01/14/2022

DOI: 10.4049/immunohorizons.2100113

PMCID: PMC9636593

PMID: 35031582

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Abstract

NK cells are important mediators of viral control with the capacity to form adaptive immune features following infection. However, studies of infection-induced adaptive NK cells require adoptive cell transfer to lower the precursor frequency of "Ag-specific" NK cells, potentially limiting the diversity of the NK cell response. In seeking an unmanipulated model to probe the adaptive NK cells, we interrogated a wide range of Collaborative Cross (CC) inbred mice, inbred mouse strains that exhibit broad genetic diversity across strains. Our assessment identified and validated a putative "ideal" CC strain, CC006, which does not require manipulation to generate and maintain adaptive NK cells. Critically, CC006 mice, in contrast to C57BL/6 mice, are capable of developing enhanced NK cell-mediated protective responses to murine CMV infection following m157-mediated vaccination. This work both furthers our understanding of adaptive NK cells and demonstrates the utility of CC mice in the development and interrogation of immunologic models.

Details

Title: Subtitle: Novel Mouse Model of Murine Cytomegalovirus-Induced Adaptive NK Cells
Creators: Isaac J Jensen - Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY; ijj2106@cumc.columbia.edu
Matthew D Martin - Department of Urology, University of Minnesota, Minneapolis, MN
Sandeep K Tripathy - Department of Medicine, Gastroenterology Division, Washington University School of Medicine, St. Louis, MO
Vladimir P Badovinac - Interdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, IA
Resource Type: Journal article
Publication Details: ImmunoHorizons, Vol.6(1), pp.8-15
DOI: 10.4049/immunohorizons.2100113
PMID: 35031582
PMCID: PMC9636593
NLM abbreviation: Immunohorizons
ISSN: 2573-7732
Language: English
Date published: 01/14/2022
Academic Unit: Pathology
Record Identifier: 9984210348402771

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