Journal article
Novel Roles for Caspase-8 in IL-1β and Inflammasome Regulation
The American journal of pathology, Vol.185(1), pp.17-25
01/2015
DOI: 10.1016/j.ajpath.2014.08.025
PMCID: PMC4278239
PMID: 25451151
Abstract
Caspase-8 is an initiator and apical activator caspase that plays a central role in apoptosis. Caspase-8–deficient mice are embryonic lethal, which makes study of caspase-8 in primary immune cells difficult. Recent advances have rescued caspase-8–deficient mice by crossing them to mice deficient in receptor-interacting serine-threonine kinase 3 (RIPK3). These genetic tools have made it possible to study the role of caspase-8
in vivo
and in primary immune cells. Several recent studies have identified novel roles for caspase-8 in modulating IL-1β and inflammation, showing that caspase-8 directly regulates IL-1β independent of inflammasomes or indirectly through the regulation of inflammasomes, depending on the stimulus or stimuli that initiate the signaling cascade. Here, we address recent findings on caspase-8 and its role in modulating IL-1β and inflammation.
Details
- Title: Subtitle
- Novel Roles for Caspase-8 in IL-1β and Inflammasome Regulation
- Creators
- Prajwal Gurung - Department of Immunology, St. Jude Children’s Research Hospital, Memphis, TennesseeThirumala-Devi Kanneganti - Department of Immunology, St. Jude Children’s Research Hospital, Memphis, Tennessee
- Resource Type
- Journal article
- Publication Details
- The American journal of pathology, Vol.185(1), pp.17-25
- Publisher
- American Society for Investigative Pathology
- DOI
- 10.1016/j.ajpath.2014.08.025
- PMID
- 25451151
- PMCID
- PMC4278239
- ISSN
- 0002-9440
- eISSN
- 1525-2191
- Language
- English
- Date published
- 01/2015
- Academic Unit
- Infectious Diseases; Internal Medicine
- Record Identifier
- 9984094380902771
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