Journal article
Novel Serum Biomarkers Associated With Pediatric Hepatic Encephalopathy: A Systematic Review
Journal of pediatric gastroenterology and nutrition, Vol.77(1), pp.16-23
07/01/2023
DOI: 10.1097/MPG.0000000000003801
PMID: 37084331
Abstract
Background:The pathophysiology of pediatric hepatic encephalopathy (HE) is not well understood. Various serum biomarkers associated with HE may provide insight into its pathology, but their use and interpretation in clinical practice for diagnosis and prognostication remain undetermined. We sought to investigate reported correlations of serum biomarkers with presence and degree of HE in children. Methods:We conducted a systematic review of studies examining novel serum biomarkers and cytokines in association with HE that included children on PubMed, Embase, Lilacs, and Scopus. We utilized Covidence for abstract and text review by 2 independent reviewers for each study. Results:We reviewed 2824 unique publications; 15 met criteria for inclusion. Categories of biomarkers reported were inflammatory cytokines, products of amino acid metabolism, trace elements and vitamins, and hepatic and neuro biomarkers. Of 19 individual biomarkers, only 5 were measured in more than 1 study. Elevations in interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) were most commonly reported as associated with HE. Notably, we observed lower average IL-6 and TNF-alpha levels in pediatric-only studies compared to mixed age studies. Overall, high bias and poor applicability to our review question was observed. We encountered low numbers of studies with pediatric focus, and few conducted with low bias study designs. Conclusion:Investigated biomarkers span a large range of categories and suggest potentially useful correlations with HE. Further well-designed prospective biomarker research is necessary to better elucidate the pathogenesis of HE in children and improve early detection and clinical care.
Details
- Title: Subtitle
- Novel Serum Biomarkers Associated With Pediatric Hepatic Encephalopathy: A Systematic Review
- Creators
- Kavita Krishnan - Loyola University ChicagoMahil Rao - Stanford UniversityNathan Chang - Stanford UniversityMay Casazza - Stanford UniversityLindsey K. Rasmussen - Stanford University
- Resource Type
- Journal article
- Publication Details
- Journal of pediatric gastroenterology and nutrition, Vol.77(1), pp.16-23
- Publisher
- Wiley
- DOI
- 10.1097/MPG.0000000000003801
- PMID
- 37084331
- ISSN
- 0277-2116
- eISSN
- 1536-4801
- Number of pages
- 8
- Language
- English
- Date published
- 07/01/2023
- Academic Unit
- Critical Care; Stead Family Department of Pediatrics
- Record Identifier
- 9984775024302771
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