Journal article
Novel and emerging therapies for B cell lymphoma
Journal of hematology and oncology, Vol.12(1), pp.82-82
07/25/2019
DOI: 10.1186/s13045-019-0752-3
PMCID: PMC6659277
PMID: 31345247
Abstract
Lymphomas are a heterogeneous group of lymphoproliferative disorders, with unique clinical and biological characteristics that exhibit variable response to therapy. Advances in chemo-immunotherapy have improved outcomes in a number of lymphoma subtypes; however, the prognosis for many patients with relapsed and refractory disease remains poor. Novel therapies including several small molecule inhibitors and chimeric antigen receptor T cells have been approved for the treatment of different lymphoma subtypes at relapse, changing the therapy landscape and further improving survival in many of these diseases. This has led to a focus on the development of new cellular therapy, antibody-based therapy, and small molecule inhibitors for relapsed and refractory disease that offer an alternative approach to cytotoxic chemotherapy. We will review these promising novel therapies and discuss their safety and efficacy in first in human studies.
Details
- Title: Subtitle
- Novel and emerging therapies for B cell lymphoma
- Creators
- Sabarish Ayyappan - The Ohio State University Wexner Medical CenterKami Maddocks - The Ohio State University Wexner Medical Center
- Resource Type
- Journal article
- Publication Details
- Journal of hematology and oncology, Vol.12(1), pp.82-82
- DOI
- 10.1186/s13045-019-0752-3
- PMID
- 31345247
- PMCID
- PMC6659277
- NLM abbreviation
- J Hematol Oncol
- ISSN
- 1756-8722
- eISSN
- 1756-8722
- Language
- English
- Date published
- 07/25/2019
- Academic Unit
- Hematology, Oncology, and Blood & Marrow Transplantation; Internal Medicine
- Record Identifier
- 9984359841102771
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