Journal article
Novel drug delivery systems for glaucoma
Eye (London), Vol.25(5), pp.578-586
05/2011
DOI: 10.1038/eye.2011.82
PMCID: PMC3171267
PMID: 21475311
Abstract
Reduction of intraocular pressure (IOP) by pharmaceutical or surgical means has long been the standard treatment for glaucoma. A number of excellent drugs are available that are effective in reducing IOP. These drugs are typically applied as eye drops. However, patient adherence can be poor, thus reducing the clinical efficacy of the drugs. Several novel delivery systems designed to address the issue of adherence and to ensure consistent reduction of IOP are currently under development. These delivery systems include contact lenses-releasing glaucoma medications, injectables such as biodegradable micro- and nanoparticles, and surgically implanted systems. These new technologies are aimed at increasing clinical efficacy by offering multiple delivery options and are capable of managing IOP for several months. There is also a desire to have complementary neuroprotective approaches for those who continue to show progression, despite IOP reduction. Many potential neuroprotective agents are not suitable for traditional oral or drop formulations. Their potential is dependent on developing suitable delivery systems that can provide the drugs in a sustained, local manner to the retina and optic nerve. Drug delivery systems have the potential to improve patient adherence, reduce side effects, increase efficacy, and ultimately, preserve sight for glaucoma patients. In this review, we discuss benefits and limitations of the current systems of delivery and application, as well as those on the horizon.
Details
- Title: Subtitle
- Novel drug delivery systems for glaucoma
- Creators
- E Lavik - Department of Biomedical Engineering, Case Western Reserve University, 10900 Euclid Ave., Cleveland, OH 44106, USA. erin.lavik@case.eduM H KuehnY H Kwon
- Resource Type
- Journal article
- Publication Details
- Eye (London), Vol.25(5), pp.578-586
- Publisher
- England
- DOI
- 10.1038/eye.2011.82
- PMID
- 21475311
- PMCID
- PMC3171267
- ISSN
- 1476-5454
- eISSN
- 1476-5454
- Grant note
- DP2 OD007338 / NIH HHS EY017142 / NEI NIH HHS DP2OD007338 / NIH HHS
- Language
- English
- Date published
- 05/2011
- Academic Unit
- Ophthalmology and Visual Sciences
- Record Identifier
- 9983979991602771
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