Journal article
Novel functions of inactive rhomboid proteins in immunity and disease
Journal of leukocyte biology, Vol.106(4), pp.823-835
10/01/2019
DOI: 10.1002/JLB.3VMR0219-069R
PMID: 31369701
Abstract
iRhoms are related to a family of intramembrane serine proteinases called rhomboids but lack proteolytic activity. In mammals, there are two iRhoms, iRhom1 and iRhom2, which have similar domain structures and overlapping specificities as well as distinctive functions. These catalytically inactive rhomboids are essential regulators for the maturation and trafficking of the disintegrin metalloprotease ADAM17 from the endoplasmic reticulum to the cell surface, and are required for the cleavage and release of a variety of membrane-associated proteins, including the IL-6 receptor, l-selectin, TNF, and EGFR ligands. iRhom2-dependent regulation of ADAM17 function has been recently implicated in the development and progression of several autoimmune diseases including rheumatoid arthritis, lupus nephritis, as well as hemophilic arthropathy. In this review, we discuss our current understanding of iRhom biology, their implications in autoimmune pathologies, and their potential as therapeutic targets.
Details
- Title: Subtitle
- Novel functions of inactive rhomboid proteins in immunity and disease
- Creators
- Ramasatyaveni Geesala - University of IowaPriya D. Issuree - Roy J. and Lucille A. Carver College of MedicineThorsten Maretzky - Holden Comprehensive Cancer Center University of Iowa Iowa City Iowa USA
- Resource Type
- Journal article
- Publication Details
- Journal of leukocyte biology, Vol.106(4), pp.823-835
- Publisher
- Wiley
- DOI
- 10.1002/JLB.3VMR0219-069R
- PMID
- 31369701
- ISSN
- 0741-5400
- eISSN
- 1938-3673
- Number of pages
- 13
- Grant note
- ACS-IRG-15-176-41 / American Cancer Society Carver College of Medicine, University of Iowa Research Start-Up Funds P30CA086862 / NATIONAL CANCER INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI)
- Language
- English
- Date published
- 10/01/2019
- Academic Unit
- Infectious Diseases; Internal Medicine
- Record Identifier
- 9984359907802771
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