Journal article
Novel genetic loci associated with hippocampal volume
Nature communications, Vol.8, 13624
01/18/2017
DOI: 10.1038/ncomms13624
PMCID: PMC5253632
PMID: 28098162
Abstract
The hippocampal formation is a brain structure integrally involved in episodic memory, spatial navigation, cognition and stress responsiveness. Structural abnormalities in hippocampal volume and shape are found in several common neuropsychiatric disorders. To identify the genetic underpinnings of hippocampal structure here we perform a genome-wide association study (GWAS) of 33,536 individuals and discover six independent loci significantly associated with hippocampal volume, four of them novel. Of the novel loci, three lie within genes (ASTN2, DPP4 and MAST4) and one is found 200 kb upstream of SHH. A hippocampal subfield analysis shows that a locus within the MSRB3 gene shows evidence of a localized effect along the dentate gyrus, subiculum, CA1 and fissure. Further, we show that genetic variants associated with decreased hippocampal volume are also associated with increased risk for Alzheimer's disease (r(g) = -0.155). Our findings suggest novel biological pathways through which human genetic variation influences hippocampal volume and risk for neuropsychiatric illness.
Details
- Title: Subtitle
- Novel genetic loci associated with hippocampal volume
- Creators
- Derrek P HibarHieab H. H AdamsNeda JahanshadGanesh ChauhanJason L SteinEdith HoferMiguel E RenteriaJoshua C BisAlejano Arias-VasquezM. Kamran IkramSylvane DesrivieresMeike W VernooijLucija AbramovicSaud AlhusainiNajaf AminMicael AnderssonKonstantinos ArfanakisBenjamin S AribisalaNicola J ArmstrongLavinia AthanasiuTomas AxelssonAshley H BeechamAlexa BeiserManon BernardSusan H BlantonMarc M BohlkenMarco P BoksJanita BraltenAdam M BrickmanOwen CarmichaelM. Mallar ChakravartyGuo-Qiang ChenChristopher R. K ChingVincent ChourakiGabriel Cuellar-PartidaFabrice CrivelloAnouk den BraberNhat Trung DoanStefan EhrlichSudheer GiddaluruAaron L GoldmanRebecca F GottesmanOliver GrimmMichael E GriswoldTulio GuadalupeBoris A GutmanJohanna HassUnn K HaukvikDavid HoehnAvram J HolmesMartine HoogmanDeborah JanowitzTianye JiaKjetil N JorgensenNazanin KarbalaiDalia KasperaviciuteSungeun KimMarieke KleinBernd KraemerPhil H LeeDavid C. M LiewaldLorna M LopezMichelle LucianoChristine MacareAne F MarquandMar MatarinKaren A MatherManuel MattheisenDavid R McKayYuri MilaneschiSusana Munoz ManiegaKwangsik NhoAllison C NugentPaul NyquistLoes M. Olde LoohuisJaap OosterlaanMartina PapmeyerLukas PirpamerBenno PuetzAdaikalavan RamasamyJennifer S RichardsShannon L RisacherRoberto Roiz-SantianezNanda RommelseStefan RopeleEmma J RoseNatalie A RoyleTatjana RundekPhilipp G SaemannArvin SaremiClaudia L SatizabalLianne SchmaalAnew J SchorkLi ShenJean ShinElena ShumskayaAlbert V SmithEmma SprootenLachlan T StrikeAlexander TeumerDiana Tordesillas-GutierrezRoberto ToroDaniah TrabzuniStella TrompetDhananjay VaidyaJeroen van der GrondSven J van der LeeDennis Van der MeerMarjolein M. J van DonkelaarKristel R van EijkTheo G. M van ErpDaan Van RooijEsther WaltonLars T WestlyeChristopher D WhelanBeverly G WindhamAnderson M WinklerKatharina WittfeldGirma WoldehawariatChristiane WolfThomas WolfersLisa R YanekJingyun YangAlex ZijdenbosMarcel P ZwiersIngrid AgartzLaura AlmasyDavid AmesPhilippe AmouyelOle A AneassenSampath ArepalliAmelia A AssarehSana BarralMark E BastinDiane M BeckerJames T BeckerDavid A BennettJohn BlangeroHans van BokhovenDorret I BoomsmaHenry BrodatyRachel M BrouwerHan G BrunnerRandy L BucknerJan K BuitelaarKazima B BulayevaWiepke CahnVince D CalhounDara M CannonGianpiero L CavalleriChing-Yu ChengSven CichonMark R CooksonAiden CorvinBenedicto Crespo-FacorroJoanne E CurranMichael CzischAnders M DaleGareth E DaviesAnton J. M De CraenEco J. C GeusPhilip L De JagerGreig I de ZubicarayIan J DearyStephanie DebetteCharles DeCarliNorman DelantyChantal DepondtAnita L DeStefanoAllissa DillmanSrdjan DjurovicGary DonohoeWayne C vetsRavi DuggiralaThomas D DyerChristian EnzingerSusanne ErkThomas EspesethIryna O FedkoGuillen FernandezLuigi FerrucciSimon E FisherDebra A FleischmanIan FordMyriam FornageTatiana M ForoudPeter T FoxClyde FrancksMasaki FukunagaJ. Raphael GibbsDavid C GlahnRandy L GollubHarald H. H GoringRobert C GreenOliver GruberVilmundur GudnasonSebastian GuelfiAsta K HabergNarelle K HansellJohn HardyCatharina A HartmanRyota HashimotoKatrin HegenscheidAneas HeinzStephanie Le HellardDena G HernandezDirk J HeslenfeldBeng-Choon HoPieter J HoekstraWolfgang HoffmannAlbert HofmanFlorian HolsboerGeorg HomuthNorbert HostenJouke-Jan HottengaMatthew HuentelmanHilleke E. Hulshoff PolMasashi IkedaClifford R JackMark JenkinsonRobert W JohnsonErik G JoenssonWouter J JukemaRene S KahnRyota KanaiIwona KloszewskaDavid S KnopmanPeter KochunovJohn B. J KwokStephen M LawrieHerve LemaitreXinmin LiuDan L LongoOscar L LopezSimon LovestoneOliver MartinezJean-Luc MartinotVenkata S MattayColm McDonaldAnew M McIntoshFrancis J McMahonKatie L McMahonPatrizia MecocciIngrid MelleAneas Meyer-LindenbergSebastian MohnkeGrant W MontgomeryDerek W MorrisThomas H MosleyThomas W MuhleisenBertram Mueller-MyhsokMichael A NallsMatthias NauckThomas E NicholsWiro J NiessenMarkus M NothenLars NybergKazutaka OhiRene L OlveraRoel A OphoffMassimo PandolfoTomas PausZdenka PausovaBrenda W. J. H PenninxG. Bruce PikeSteven G PotkinBruce M PsatySimone ReppermundMarcella RietschelJoshua L RoffmanNina Romanczuk-SeiferthJerome I RotterMina RytenRalph L SaccoPerminder S SachdevAnew J SaykinReinhold SchmidtHelena SchmidtPeter R SchofieldSigurdur SigurssonAnew SimmonsAnew SingletonSanjay M SisodiyaColin SmithJordan W SmollerHilkka SoininenVidar M SteenDavid J StottJessika E SussmannAnbupalam ThalamuthuArthur W TogaBryan J TraynorJuan TroncosoMagda TsolakiChristophe TzourioAne G UitterlindenMaria C. Valdes HernandezMarcel P. van der BrugAad van der LugtNic J A van der WeeNeeltje E. M van HarenDennis van't EntMarie-Jose Van TolBai N VardarajanBruno VellasDick. J VeltmanHenry VoelzkeHenrik WalterJoanna M WardlawThomas H WassinkMichael E WealeDaniel R WeinbergerMichael W WeinerWei WenEric WestmanTonya WhiteTien Y WongClinton B WrightRonald H ZielkeAlan B ZondermanNicholas G MartinCornelia Mvan DuijnMargaret J WrightW. T LongstrethGunter SchumannHans J GrabeBarbara FrankeLenore J LaunerSarah E MedlandSudha SeshaiPaul M ThompsonM. Arfan Ikram
- Resource Type
- Journal article
- Publication Details
- Nature communications, Vol.8, 13624
- DOI
- 10.1038/ncomms13624
- PMID
- 28098162
- PMCID
- PMC5253632
- NLM abbreviation
- Nat Commun
- ISSN
- 2041-1723
- eISSN
- 2041-1723
- Language
- English
- Date published
- 01/18/2017
- Academic Unit
- Psychiatry; Stead Family Department of Pediatrics
- Record Identifier
- 9984280836102771
Metrics
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