Journal article
Novel hypertension phenotypes based on cross-classification of 24-h brachial and aortic SBP
Journal of hypertension, Vol.44(9), pp.1605-1616
09/2026
DOI: 10.1097/HJH.0000000000004376
PMID: 42299866
Abstract
Novel hypertension phenotypes are described by cross-classification of brachial and aortic SBP (brSBP/aoSBP).
The aim of this study is to examine their prevalence and age and sex-distribution, factors that potentially modulate them, and their association with left ventricular hypertrophy (LVH).
Data on 24-h ambulatory BP monitoring (ABPM) using the Mobilograph device (IEM GmbH, Stolberg, Germany) and LVH from the International 24-h Ambulatory aortic Blood pressure Consortium (i24ABC) were retrieved from 31 centers (17 countries). The population was categorized into four phenotypes; concordant systolic normotension (CSN: both SBPs normal), isolated brachial systolic hypertension (IbrSH: high brSBP/normal aoSBP), isolated aortic systolic hypertension (IaoSH: normal brSBP/high aoSBP), and concordant systolic hypertension (CSH: both SBPs high).
In 8738 participants (age: 58.4 ± 15.1 years; 51.8% men), the prevalence of IaoSH was 7.7%, being more prevalent in men, and presenting a U-shape age-distribution in them compared to a linear distribution in females. IaoSH was associated with lower heart rate and beta-blockade medications. The prevalence of IbrSH was 6.5%, presenting an inverted U-shape age-distribution; it was higher in the presence of higher heart rate and calcium channel-blockade. In 2307 individuals with LVH data, after adjustment for age, sex, DBP, IaoSH - but not IbrSH - had 2.6 higher odds of LVH compared to CSN (95% confidence interval, 1.7-3.9) and similar to CSH.
IaoSH and IbrSH amounted to almost 15% and showed specific clinic characteristics. Only IaoSH was significantly associated with LVH. Outcome-driven randomized controlled trials are needed to further investigate their clinical relevance.
Details
- Title: Subtitle
- Novel hypertension phenotypes based on cross-classification of 24-h brachial and aortic SBP
- Creators
- Elpida Athanasopoulou - National and Kapodistrian University of AthensThomas Weber - Klinikum Wels-GrieskirchenJames E Sharman - University of TasmaniaSiegfried Wassertheurer - Austrian Institute of TechnologyMohsen Agharazii - Université LavalAntonios Argyris - National and Kapodistrian University of AthensSola Aoun Bahous - Lebanese American UniversityJose R Banegas - Universidad Autónoma de MadridRonald K Binder - Klinikum Wels-GrieskirchenJacques Blacher - Hôtel-Dieu de ParisAndréa Araujo Brandao - Universidade do Estado do Rio de JaneiroKathrin Danninger - Klinikum Wels-GrieskirchenPeter Fitscha - Statistics AustriaCristina Giannattasio - Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano NiguardaEugenia Gkaliagkousi - Aristotle University of ThessalonikiAnnelise Machado Gomes de Paiva - Dr Marco Mota Clinical Research Center - Cesmac University Center, Alagoas, BrazilAuxiliadora Graciani - Centro de Investigación Biomédica en Red de Epidemiología y Salud PúblicaBernhard Hametner - Austrian Institute of TechnologyPiotr Jankowski - Postgraduate School of Molecular MedicineFotios Karachalias - National and Kapodistrian University of AthensKazuomi Kario - Jichi Medical UniversityAnastasios Kollias - National and Kapodistrian University of AthensAntonios Lazaridis - Aristotle University of ThessalonikiYan Li - Ruijin HospitalAlessandro Maloberti - Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano NiguardaChristopher C Mayer - Austrian Institute of TechnologyBarry J McDonnell - Cardiff Metropolitan UniversityCarmel M McEniery - Addenbrooke's HospitalMarco Antonio Mota-Gomes - Universidade do Estado do Rio de JaneiroMaria Lorenza Muiesan - University of BresciaJános Nemcsik - Semmelweis UniversityAnna Paini - University of BresciaSabine Perl - Medical University of GrazGary L Pierce - University of IowaDaniel Piskorz - Hospital Británico de Buenos AiresGiacomo Pucci - University of PerugiaEva Reininghaus - Medical University of GrazBernd Reininghaus - Medical University of GrazEnrique Rodilla Sala - Universidad Cardenal Herrera CEUAletta E Schutte - Hypertension in Africa Research Team (HART), SAMRC Unit for Hypertension and Cardiovascular Disease, North-West University, Potchefstroom, South AfricaPetros P Sfikakis - National and Kapodistrian University of AthensAlejandro de la Sierra - University Hospital Mútua de TerrassaGeorge S Stergiou - National and Kapodistrian University of AthensDimitrios Terentes-Printzios - National and Kapodistrian University of AthensCharalambos Vlachopoulos - National and Kapodistrian University of AthensLisa J Ware - South African Medical Research CouncilIan B Wilkinson - Addenbrooke's HospitalYi Zhang - Shanghai Tenth People's HospitalAthanase D Protogerou - National and Kapodistrian University of AthensInternational Academic 24-Hour Ambulatory Aortic Blood Pressure Consortium (i24abc.org)
- Resource Type
- Journal article
- Publication Details
- Journal of hypertension, Vol.44(9), pp.1605-1616
- DOI
- 10.1097/HJH.0000000000004376
- PMID
- 42299866
- NLM abbreviation
- J Hypertens
- ISSN
- 1473-5598
- eISSN
- 1473-5598
- Publisher
- LIPPINCOTT WILLIAMS & WILKINS
- Grant note
- Scholarship received from the Hellenic Society of Hypertension Hungarian Society of Hypertension Russell B. Day and Florence D. Day Chair in Liberal Arts and Sciences at the University of Iowa Instituto de Salud Carlos III (ISCIII) (FIS): 22/1164 European Social Fund/European Regional Development fund Fonds de recherche du Quebec (FRC) through the research centre grant for the CHU de de Quebec-Univrsite Laval Research Center: 30641 Shanghai Commissions of Health: 2022LJ022 National Natural Science Foundation of China: 82270469 Investigator Grant from the National Health and Medical Research Council of Australia: APP2017504 British Heart Foundation: PG/11/35/28879 NIHR Biomedical Research Centre: BRC-1215-20014
Amy Stroud for instrumentation and acquisition of 24-h ABPM data in research for the Department of Health and Human Physiology, University of Iowa, Iowa City, USA.The International 24-h Ambulatory aortic Blood Pressure Consortium (i24ABC) is a purely academic research project without industry funding.E. Athanasopoulou was supported by a scholarship received from the Hellenic Society of Hypertension.J. Nemcsik was supported by the Hungarian Society of Hypertension.G.L. Pierce is supported by the Russell B. Day and Florence D. Day Chair in Liberal Arts and Sciences at the University of Iowa.J.R. Banegas was funded by the Instituto de Salud Carlos III (ISCIII) (FIS grant 22/1164) and the European Social Fund/European Regional Development fund.M. Agharazii: This work was supported by the Fonds de recherche du Quebec (FRC) through the research centre grant for the CHU de de Quebec-Univrsite Laval Research Center (reference: 30641).Y. Li is currently supported by grants from Shanghai Commissions of Health ("Leading Academics" 2022LJ022) and National Natural Science Foundation of China (82270469).A.E. Schutte was supported by an Investigator Grant from the National Health and Medical Research Council of Australia (APP2017504).C.M. McEniery was supported by grants received from British Heart Foundation (PG/11/35/28879) and the NIHR Biomedical Research Centre (BRC-1215-20014). The views expressed are those of the authors and not necessarily those of the NIHR or the Department of Health and Social Care.L.J. Ware is supported by a career development award from the Wellcome Trust UK (301436/Z/23/Z).
- Language
- English
- Electronic publication date
- 06/16/2026
- Date published
- 09/2026
- Academic Unit
- Health, Sport, and Human Physiology ; Internal Medicine
- Record Identifier
- 9985175460102771
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