Journal article
Novel management of urinary tract infections
Current opinion in urology, Vol.21(4), pp.328-333
07/2011
DOI: 10.1097/MOU.0b013e328346d4ee
PMID: 21519273
Abstract
To highlight observations that have suggested the need for changing the conventional approach to the evaluation and management of urinary tract infections (UTIs) and vesicoureteral reflux in children and examine new alternative approaches to prevention of UTI and renal scarring based on research into host-pathogen interaction.
Recent studies have questioned the traditional approach of using prophylactic antibiotics to prevent recurrence of UTI and development of renal scarring in children with vesicoureteral reflux. Ongoing research on host-pathogen interactions reveals a promising capability to analyze virulence factors in bacteria causing UTIs in children, identify highly virulent bacteria capable of causing pyelonephritis and renal injury, and to selectively target the gastrointestinal reservoirs of these bacteria for elimination using probiotics.
Promising experimental studies correlating bacterial virulence with pattern of UTI and identification and characterization of a newly available probiotic capable of eradicating uropathogenic bacteria make targeted probiotic prevention of renal injury-inducing UTIs a potential therapeutic reality.
Details
- Title: Subtitle
- Novel management of urinary tract infections
- Creators
- Douglas W Storm - Department of Urology, Naval Medical Center, San Diego, California, USAAshay S PatelStephen A KoffSheryl S Justice
- Resource Type
- Journal article
- Publication Details
- Current opinion in urology, Vol.21(4), pp.328-333
- Publisher
- United States
- DOI
- 10.1097/MOU.0b013e328346d4ee
- PMID
- 21519273
- ISSN
- 0963-0643
- eISSN
- 1473-6586
- Language
- English
- Date published
- 07/2011
- Academic Unit
- Stead Family Department of Pediatrics; Urology
- Record Identifier
- 9984051774002771
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