Journal article
Novel mechanisms contributing to cerebral vascular dysfunction during chronic hypertension
Current hypertension reports, Vol.3(6), pp.517-523
11/2001
DOI: 10.1007/s11906-001-0015-9
PMID: 11734099
Abstract
Chronic hypertension is a major risk factor for numerous cardiovascular disorders and is strongly associated with stroke. Hypertension alters cerebral vascular structure and may have profound deleterious effects on cerebral vascular function, the underlying mechanisms of which are still not well understood. Recent findings have led to important developments in our understanding of novel areas of cerebral vascular biology. This review briefly examines new evidence for physiologic and pathologic roles of K(+) channels, the renin-angiotensin system and reactive oxygen species, and Rho and Rho-kinase in regulation of cerebral vascular tone.
Details
- Title: Subtitle
- Novel mechanisms contributing to cerebral vascular dysfunction during chronic hypertension
- Creators
- Christopher G SobeyFrank M Faraci
- Resource Type
- Journal article
- Publication Details
- Current hypertension reports, Vol.3(6), pp.517-523
- DOI
- 10.1007/s11906-001-0015-9
- PMID
- 11734099
- ISSN
- 1522-6417
- eISSN
- 1534-3111
- Language
- English
- Date published
- 11/2001
- Academic Unit
- Cardiovascular Medicine; Neuroscience and Pharmacology; Internal Medicine
- Record Identifier
- 9984040307402771
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