Journal article
Novel risk score for predicting acute cardiovascular and cerebrovascular events after chest radiotherapy in patients with breast or lung cancer
European journal of preventive cardiology, Vol.33(4), pp.513-525
03/2026
DOI: 10.1093/eurjpc/zwae323
PMCID: PMC13159028
PMID: 39453776
Abstract
The risk for major acute cardiovascular and cerebrovascular events after RT for breast and lung cancer can be stratified by simple, easy to use and effective tools, even before chest radiation. This information can be used for shared decision making and treatment planning, as well as incentivizing optimal cardiovascular risk factor and disease management. Post-therapy model (C2AD2) included CAC (2 points), MACCE history (2 points), age >= 74 (3 points), DM (2 points), and mean heart radiation dose >= 850 mGy (2 points), and pre-therapy model (C2AD) included post-therapy model parameters minus mean heart radiation dose. Both models stratified into three risk groups: low (0-2), intermediate (3-5), and high (>= 6).Post-RT MACCE occurred in 6.1 and 5.6% in the derivation and validation cohort over a mean follow-up of 42 +/- 13 months.Post-RT MACCE across these groups were 2.7, 8.9, and 19.8% in the derivation, and 3.9, 6.6, and 16.4% in the validation cohort for post-therapy model (C2AD2) and 2.8, 9.2, and 20.4% in the derivation and 3.7, 9.2, and 13.2% in the validation cohort for pre-therapy model. Both models showed statistically significant graded survival outcome.
Details
- Title: Subtitle
- Novel risk score for predicting acute cardiovascular and cerebrovascular events after chest radiotherapy in patients with breast or lung cancer
- Creators
- Anan Abu Rmilah - Mayo ClinicAlkurashi Adham - Mayo ClinicHaq Ikram-Ul - Mayo ClinicHossam Alzu'bi - Mayo ClinicAnevakar Nandan - Mayo ClinicHayan Jouni - Mayo ClinicSatomi Hirashi - Mayo ClinicDawn Owen - Mayo ClinicAnita Deswal - The University of Texas MD Anderson Cancer CenterSteven H. Lin - The University of Texas MD Anderson Cancer CenterJun-Ichi Abe - The University of Texas MD Anderson Cancer CenterTzu Cheng Chao - Mayo ClinicJacinta Browne - Mayo ClinicTim Leiner - Mayo ClinicNadia Laack - Mayo ClinicJoerg Herrmann - Mayo Clinic
- Resource Type
- Journal article
- Publication Details
- European journal of preventive cardiology, Vol.33(4), pp.513-525
- DOI
- 10.1093/eurjpc/zwae323
- PMID
- 39453776
- PMCID
- PMC13159028
- NLM abbreviation
- Eur J Prev Cardiol
- ISSN
- 2047-4873
- eISSN
- 2047-4881
- Publisher
- Oxford Univ Press
- Number of pages
- 13
- Grant note
- CA233610 / NIH/NCI; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) Miami Heart Research Institute Mayo Clinic Department of Cardiovascular Diseases
- Language
- English
- Electronic publication date
- 10/25/2024
- Date published
- 03/2026
- Academic Unit
- Internal Medicine
- Record Identifier
- 9984845670502771
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