Novel strategy for a cocktail 18F-fluoride and 18F-FDG PET/CT scan for evaluation of malignancy: results of the pilot-phase study

Andrei Iagaru; Erik Mittra; Shahriar S Yaghoubi; David W Dick; Andrew Quon; Michael L Goris; Sanjiv Sam Gambhir

doi:10.2967/jnumed.108.058339

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Novel strategy for a cocktail 18F-fluoride and 18F-FDG PET/CT scan for evaluation of malignancy: results of the pilot-phase study

Journal article

Open access

Peer reviewed

Novel strategy for a cocktail 18F-fluoride and 18F-FDG PET/CT scan for evaluation of malignancy: results of the pilot-phase study

Andrei Iagaru, Erik Mittra, Shahriar S Yaghoubi, David W Dick, Andrew Quon, Michael L Goris and Sanjiv Sam Gambhir

The Journal of nuclear medicine (1978), Vol.50(4), pp.501-505

04/2009

DOI: 10.2967/jnumed.108.058339

PMID: 19289439

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Abstract

(18)F-FDG PET/CT is used for detecting cancer and monitoring cancer response to therapy. However, because of the variable rates of glucose metabolism, not all cancers are identified reliably. Sodium (18)F was previously used for bone imaging and can be used as a PET/CT skeletal tracer. The combined administration of (18)F and (18)F-FDG in a single PET/CT study for cancer detection has not been reported to date. This is a prospective pilot study (November 2007-November 2008) of 14 patients with proven malignancy (6 sarcoma, 3 prostate cancer, 2 breast cancer, 1 colon cancer, 1 lung cancer, and 1 malignant paraganglioma) who underwent separate (18)F PET/CT and (18)F-FDG PET/CT and combined (18)F/(18)F-FDG PET/CT scans for the evaluation of malignancy (a total of 3 scans each). There were 11 men and 3 women (age range, 19-75 y; average, 50.4 y). Interpretation of the combined (18)F/(18)F-FDG PET/CT scans compared favorably with that of the (18)F-FDG PET/CT (no lesions missed) and the (18)F PET/CT scans (only 1 skull lesion seen on an (18)F PET/CT scan was missed on the corresponding combined scan). Through image processing, the combined (18)F/(18)F-FDG scan yielded results for bone radiotracer uptake comparable to those of the (18)F PET/CT scan performed separately. Our pilot-phase prospective trial demonstrates that the combined (18)F/(18)F-FDG administration followed by a single PET/CT scan is feasible for cancer detection. This combined method opens the possibility for improved patient care and reduction in health care costs.

Reproducibility of Results

Humans

Middle Aged

Tomography, X-Ray Computed - methods

Male

Neoplasms - diagnosis

Positron-Emission Tomography - methods

Subtraction Technique

Young Adult

Pilot Projects

Animals

Sensitivity and Specificity

Adult

Female

Fluorodeoxyglucose F18

Aged

Image Enhancement - methods

Mice

Radiopharmaceuticals

Details

Title: Subtitle: Novel strategy for a cocktail 18F-fluoride and 18F-FDG PET/CT scan for evaluation of malignancy: results of the pilot-phase study
Creators: Andrei Iagaru - Division of Nuclear Medicine, Stanford University Medical Center, Stanford, California, USA
Erik Mittra
Shahriar S Yaghoubi
David W Dick
Andrew Quon
Michael L Goris
Sanjiv Sam Gambhir
Resource Type: Journal article
Publication Details: The Journal of nuclear medicine (1978), Vol.50(4), pp.501-505
DOI: 10.2967/jnumed.108.058339
PMID: 19289439
NLM abbreviation: J Nucl Med
ISSN: 0161-5505
eISSN: 1535-5667
Publisher: United States
Grant note: CA114747 / NCI NIH HHS
Language: English
Date published: 04/2009
Academic Unit: Radiology; Pharmaceutical Sciences and Experimental Therapeutics
Record Identifier: 9984051867102771

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