Journal article
Novel treatments for chronic pain: moving beyond opioids
Translational research : the journal of laboratory and clinical medicine, Vol.234, pp.1-19
03/13/2021
DOI: 10.1016/j.trsl.2021.03.008
PMID: 33727192
Abstract
It is essential that safe and effective treatment options be available to patients suffering from chronic pain. The emergence of an opioid epidemic has shaped public opinions and created stigmas surrounding the use of opioids for the management of pain. This reality, coupled with high risk of adverse effects from chronic opioid use, has led chronic pain patients and their healthcare providers to utilize nonopioid treatment approaches. In this review, we will explore a number of cellular reorganizations that are associated with the development and progression of chronic pain. We will also discuss the safety and efficacy of opioid and nonopioid treatment options for chronic pain. Finally, we will review the evidence for adenylyl cyclase type 1 (AC1) as a novel target for the treatment of chronic pain.
Details
- Title: Subtitle
- Novel treatments for chronic pain: moving beyond opioids
- Creators
- Joseph B O'Brien - Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, University of Iowa, Iowa City, IowaDavid L Roman - Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, University of Iowa, Iowa City, Iowa
- Resource Type
- Journal article
- Publication Details
- Translational research : the journal of laboratory and clinical medicine, Vol.234, pp.1-19
- Publisher
- Elsevier Inc
- DOI
- 10.1016/j.trsl.2021.03.008
- PMID
- 33727192
- ISSN
- 1931-5244
- eISSN
- 1878-1810
- Grant note
- DOI: 10.13039/100000057, name: National Institute of General Medical Sciences; DOI: 10.13039/100000065, name: National Institute of Neurological Disorders and Stroke
- Language
- English
- Date published
- 03/13/2021
- Academic Unit
- Pharmacy; Iowa Neuroscience Institute; Pharmaceutical Sciences and Experimental Therapeutics; Medicinal and Natural Products Chemistry
- Record Identifier
- 9984070529902771
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