Novelty-induced frontal-STN networks in Parkinson's disease

Rachel C Cole; Arturo I Espinoza; Arun Singh; Joel I Berger; James F Cavanagh; Jan R Wessel; Jeremy D Greenlee; Nandakumar S Narayanan

doi:10.1093/cercor/bhac078

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Novelty-induced frontal-STN networks in Parkinson's disease

Journal article

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Peer reviewed

Novelty-induced frontal-STN networks in Parkinson's disease

Rachel C Cole, Arturo I Espinoza, Arun Singh, Joel I Berger, James F Cavanagh, Jan R Wessel, Jeremy D Greenlee and Nandakumar S Narayanan

Cerebral cortex (New York, N.Y. 1991), Vol.33(2), pp.469-485

01/15/2023

DOI: 10.1093/cercor/bhac078

PMCID: PMC9837604

PMID: 35297483

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https://academic.oup.com/cercor/article/33/2/469/6549859View

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Abstract

Novelty detection is a primitive subcomponent of cognitive control that can be deficient in Parkinson's disease (PD) patients. Here, we studied the corticostriatal mechanisms underlying novelty-response deficits. In participants with PD, we recorded from cortical circuits with scalp-based electroencephalography (EEG) and from subcortical circuits using intraoperative neurophysiology during surgeries for implantation of deep brain stimulation (DBS) electrodes. We report three major results. First, novel auditory stimuli triggered midfrontal low-frequency rhythms; of these, 1-4 Hz "delta" rhythms were linked to novelty-associated slowing, whereas 4-7 Hz "theta" rhythms were specifically attenuated in PD. Second, 32% of subthalamic nucleus (STN) neurons were response-modulated; nearly all (94%) of these were also modulated by novel stimuli. Third, response-modulated STN neurons were coherent with midfrontal 1-4 Hz activity. These findings link scalp-based measurements of neural activity with neuronal activity in the STN. Our results provide insight into midfrontal cognitive control mechanisms and how purported hyperdirect frontobasal ganglia circuits evaluate new information.

oddball task

cognitive control

neuronal spiking

neuronal coherence

prefrontal cortex

Details

Title: Subtitle: Novelty-induced frontal-STN networks in Parkinson's disease
Creators: Rachel C Cole - University of Iowa
Arturo I Espinoza - University of Iowa
Arun Singh - University of South Dakota
Joel I Berger - University of Iowa
James F Cavanagh - Department of Psychology, University of New Mexico, 2001 Redondo S Dr, Albuquerque, NM 87106, United States
Jan R Wessel - University of Iowa
Jeremy D Greenlee - University of Iowa
Nandakumar S Narayanan - University of Iowa
Resource Type: Journal article
Publication Details: Cerebral cortex (New York, N.Y. 1991), Vol.33(2), pp.469-485
DOI: 10.1093/cercor/bhac078
PMID: 35297483
PMCID: PMC9837604
NLM abbreviation: Cereb Cortex
eISSN: 1460-2199
Grant note: F32 AG069445-01 / NIA NIH HHS P20NS123151 / NINDS NIH HHS UL1TR002537 / NIH HHS
Language: English
Electronic publication date: 03/17/2022
Date published: 01/15/2023
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Neurology; Stead Family Department of Pediatrics; Psychological and Brain Sciences; Iowa Neuroscience Institute; Neurosurgery; Otolaryngology
Record Identifier: 9984229187202771

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