Novelty-induced locomotion is positively associated with cocaine ingestion in adolescent rats; anxiety is correlated in adults

Q. David WALKER; Nicole L SCHRAMM-SAPYTA; Joseph M CASTER; Samuel T WALLER; Matthew P BROOKS; Cynthia M KUHN

doi:10.1016/j.pbb.2008.08.019

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Novelty-induced locomotion is positively associated with cocaine ingestion in adolescent rats; anxiety is correlated in adults

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Novelty-induced locomotion is positively associated with cocaine ingestion in adolescent rats; anxiety is correlated in adults

Q. David WALKER, Nicole L SCHRAMM-SAPYTA, Joseph M CASTER, Samuel T WALLER, Matthew P BROOKS and Cynthia M KUHN

Pharmacology, biochemistry and behavior, Vol.91(3), pp.398-408

2009

DOI: 10.1016/j.pbb.2008.08.019

PMCID: PMC2715835

PMID: 18790706

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https://www.ncbi.nlm.nih.gov/pmc/articles/2715835View

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Abstract

The present studies assessed the roles of sex, age, novelty-seeking and plus-maze behavior on cocaine drinking in rats. Cocaine/saccharin solution was available in three daily, 5-hour sessions then a saccharin-only solution was also available in following sessions. In the one-bottle drinking phase, early and late adolescent males, post-natal day 28 (PN28) and PN42, consumed more cocaine/saccharin solution than young adults (PN65), but females did not exhibit significant age differences. Adolescents of both sexes consumed more cocaine/saccharin than adults during choice drinking. Saccharin availability in the two-bottle trials decreased cocaine/saccharin consumption in PN28 and PN65 rats. After a drug-free period, cocaine-stimulated locomotion was lower in cocaine/saccharin drinking than saccharin-only males, indicating tolerance. We tested the hypothesis that individual differences in pre-screened behavioral traits would correlate with cocaine/saccharin consumption in PN28 and PN65 male rats. High locomotor responses to novelty were associated with greater cocaine/saccharin drinking in adults in one-bottle sessions. In the subsequent choice drinking phase, correlations were age-specific. Adolescents with high novelty-induced locomotion and adults that spent less time on open arms of the elevated plus-maze drank more cocaine/saccharin. Thus, behavioral phenotypes correlated with individual differences in cocaine/saccharin consumption in an age-related manner.

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Details

Title: Subtitle: Novelty-induced locomotion is positively associated with cocaine ingestion in adolescent rats; anxiety is correlated in adults
Creators: Q. David WALKER - Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, United States
Nicole L SCHRAMM-SAPYTA - Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, United States
Joseph M CASTER - Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, United States
Samuel T WALLER - Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, United States
Matthew P BROOKS - Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, United States
Cynthia M KUHN - Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, United States
Resource Type: Journal article
Publication Details: Pharmacology, biochemistry and behavior, Vol.91(3), pp.398-408
DOI: 10.1016/j.pbb.2008.08.019
PMID: 18790706
PMCID: PMC2715835
NLM abbreviation: Pharmacol Biochem Behav
ISSN: 0091-3057
eISSN: 1873-5177
Publisher: Elsevier; Kidlington
Language: English
Date published: 2009
Academic Unit: Radiation Oncology
Record Identifier: 9984046910302771

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