Journal article
Nox1 in cardiovascular diseases: regulation and pathophysiology
Clinical science (1979), Vol.130(3), pp.151-165
02/01/2016
DOI: 10.1042/CS20150404
PMID: 26678171
Abstract
Since its discovery in 1999, a number of studies have evaluated the role of Nox1 NADPH oxidase in the cardiovascular system. Nox1 is activated in vascular cells in response to several different agonists, with its activity regulated at the transcriptional level as well as by NADPH oxidase complex formation, protein stabilization and post-translational modification. Nox1 has been shown to decrease the bioavailability of nitric oxide, transactivate the epidermal growth factor receptor, induce pro-inflammatory signalling, and promote cell migration and proliferation. Enhanced expression and activity of Nox1 under pathologic conditions results in excessive production of reactive oxygen species and dysregulated cellular function. Indeed, studies using genetic models of Nox1 deficiency or overexpression have revealed roles for Nox1 in the pathogenesis of cardiovascular diseases ranging from atherosclerosis to hypertension, restenosis and ischaemia/reperfusion injury. These data suggest that Nox1 is a potential therapeutic target for vascular disease, and drug development efforts are ongoing to identify a specific bioavailable inhibitor of Nox1.
Details
- Title: Subtitle
- Nox1 in cardiovascular diseases: regulation and pathophysiology
- Creators
- Marcela Gimenez - University of IowaBrandon M. Schickling - University of IowaLucia R. Lopes - Universidade de São PauloFrancis J. Miller - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Clinical science (1979), Vol.130(3), pp.151-165
- DOI
- 10.1042/CS20150404
- PMID
- 26678171
- NLM abbreviation
- Clin Sci (Lond)
- ISSN
- 0143-5221
- eISSN
- 1470-8736
- Publisher
- Portland Press Ltd
- Number of pages
- 15
- Grant note
- 1BX001729 / United States Department of Veterans Affairs Biomedical Laboratory Research and Development Program 475609/2013-1 / Conselho Nacional de Desenvolvimento Cientifico e Tecnologico CNPq; Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPQ) 13/18300-0 / Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) 2013/18300-0; 2009/54764-6; 2013/03520-5; 2013/07937-8 / Sao Paulo Research Foundation; Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) GRNT12060205 / American Heart Association
- Language
- English
- Date published
- 02/01/2016
- Academic Unit
- Obstetrics and Gynecology
- Record Identifier
- 9984966851902771
Metrics
2 Record Views