Nuclear MTA1 overexpression is associated with aggressive prostate cancer, recurrence and metastasis in African Americans

Steven J Dias; Xinchun Zhou; Marina Ivanovic; Michael P Gailey; Swati Dhar; Liangfen Zhang; Zhi He; Alan D Penman; Srinivasan Vijayakumar; Anait S Levenson

doi:10.1038/srep02331

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Nuclear MTA1 overexpression is associated with aggressive prostate cancer, recurrence and metastasis in African Americans

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Nuclear MTA1 overexpression is associated with aggressive prostate cancer, recurrence and metastasis in African Americans

Steven J Dias, Xinchun Zhou, Marina Ivanovic, Michael P Gailey, Swati Dhar, Liangfen Zhang, Zhi He, Alan D Penman, Srinivasan Vijayakumar and Anait S Levenson

Scientific reports, Vol.3(1), pp.2331-2331

2013

DOI: 10.1038/srep02331

PMCID: PMC3728596

PMID: 23900262

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Abstract

Metastasis-associated protein 1 (MTA1), a negative epigenetic modifier, plays a critical role in prostate cancer (PCa) progression. We hypothesized that MTA1 overexpression in primary tumor tissues can predict PCa aggressiveness and metastasis. Immunohistochemical staining of MTA1 was done on archival PCa specimens from University of Mississippi Medical Center and University of Iowa. We found that nuclear MTA1 overexpression was positively correlated with the severity of disease progression reaching its highest levels in metastatic PCa. Nuclear MTA1 overexpression was significantly associated with Gleason > 7 tumors in African Americans but not in Caucasians. It was also a predictor of recurrent disease. We concluded that MTA1 nuclear overexpression may be a prognostic indicator and a future therapeutic target for aggressive PCa in African American men. Our findings may be useful for categorizing African American patients with a higher probability of recurrent disease and metastasis from those who are likely to remain metastasis-free.

Details

Title: Subtitle: Nuclear MTA1 overexpression is associated with aggressive prostate cancer, recurrence and metastasis in African Americans
Creators: Steven J Dias - University of Mississippi Medical Center
Xinchun Zhou - University of Mississippi Medical Center
Marina Ivanovic - University of Iowa
Michael P Gailey - University of Iowa
Swati Dhar - University of Mississippi Medical Center
Liangfen Zhang - University of Mississippi Medical Center
Zhi He - University of Mississippi Medical Center
Alan D Penman - University of Mississippi Medical Center
Srinivasan Vijayakumar - University of Mississippi Medical Center
Anait S Levenson - University of Mississippi Medical Center
Resource Type: Journal article
Publication Details: Scientific reports, Vol.3(1), pp.2331-2331
DOI: 10.1038/srep02331
PMID: 23900262
PMCID: PMC3728596
NLM abbreviation: Sci Rep
ISSN: 2045-2322
eISSN: 2045-2322
Publisher: Nature Publishing Group
Language: English
Date published: 2013
Academic Unit: Pathology
Record Identifier: 9984201258402771

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