Journal article
Nuclear architecture as an intrinsic regulator of Drosophila female germline stem cell maintenance
Current opinion in insect science, Vol.37, pp.30-38
02/01/2020
DOI: 10.1016/j.cois.2019.11.007
PMCID: PMC7089816
PMID: 32087561
Abstract
Homeostasis of Drosophila germline stem cells (GSC) depends upon the integration of intrinsic and extrinsic signals. This review highlights emerging data that support nuclear architecture as an intrinsic regulator of GSC maintenance and germ cell differentiation. Here, we focus on the nuclear lamina (NL) and the nucleolus, two compartments that undergo alterations in composition upon germ cell differentiation. Loss of NL or nucleolar components leads to GSC loss, resulting from activation of GSC quality control checkpoint pathways. We suggest that the NL and nucleolus integrate signals needed for the switch between GSC maintenance and germ cell differentiation, and propose regulation of nuclear actin pools as one mechanism that connects these compartments.
Details
- Title: Subtitle
- Nuclear architecture as an intrinsic regulator of Drosophila female germline stem cell maintenance
- Creators
- Tingting Duan - University of IowaNicole Green - University of IowaTina L. Tootle - University of IowaPamela K. Geyer - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Current opinion in insect science, Vol.37, pp.30-38
- DOI
- 10.1016/j.cois.2019.11.007
- PMID
- 32087561
- PMCID
- PMC7089816
- NLM abbreviation
- Curr Opin Insect Sci
- ISSN
- 2214-5745
- eISSN
- 2214-5753
- Publisher
- Elsevier
- Number of pages
- 9
- Grant note
- University of Iowa, Anatomy and Cell Biology Department GM087341; GM116885 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA
- Language
- English
- Date published
- 02/01/2020
- Academic Unit
- Anatomy and Cell Biology; Obstetrics and Gynecology; Biochemistry and Molecular Biology
- Record Identifier
- 9984284456902771
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