Nuclear organization: taking a position on gene expression

Pamela K Geyer; Michael W Vitalini; Lori L Wallrath

doi:10.1016/j.ceb.2011.03.002

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Nuclear organization: taking a position on gene expression

Journal article

Open access

Peer reviewed

Nuclear organization: taking a position on gene expression

Pamela K Geyer, Michael W Vitalini and Lori L Wallrath

Current opinion in cell biology, Vol.23(3), pp.354-359

06/2011

DOI: 10.1016/j.ceb.2011.03.002

PMCID: PMC4160055

PMID: 21450447

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Abstract

Eukaryotic genomes are divided into chromosomes that occupy defined regions or territories within the nucleus. These chromosome territories (CTs) are arranged based on the transcriptional activity and chromatin landscape of domains. In general, transcriptionally silent domains reside at the nuclear periphery, whereas active domains locate within the interior. Changes in nuclear position are observed for stress-induced and developmentally regulated tissue-specific genes. Upon activation, these genes move away from a CT to inter-chromosomal space containing nuclear bodies enriched in gene expression machinery. Gene activation is not always accompanied by movement, as positioning is dictated by many determinants, including gene structure and the local genomic environment. Collectively, tissue-specific nuclear organization results from a culmination of inputs that result in proper transcriptional regulation.

Chromatin - metabolism

Animals

Cell Nucleus - genetics

Humans

Transcriptional Activation

Gene Expression Regulation

Cell Nucleus - chemistry

Chromosomes

Details

Title: Subtitle: Nuclear organization: taking a position on gene expression
Creators: Pamela K Geyer - University of Iowa, Iowa City, IA 52242, United States
Michael W Vitalini
Lori L Wallrath
Resource Type: Journal article
Publication Details: Current opinion in cell biology, Vol.23(3), pp.354-359
DOI: 10.1016/j.ceb.2011.03.002
PMID: 21450447
PMCID: PMC4160055
NLM abbreviation: Curr Opin Cell Biol
ISSN: 0955-0674
eISSN: 1879-0410
Publisher: England
Grant note: GM087341 / NIGMS NIH HHS GM085974 / NIGMS NIH HHS GM042539 / NIGMS NIH HHS R01 GM087341 / NIGMS NIH HHS F32 GM085974 / NIGMS NIH HHS GM061513 / NIGMS NIH HHS R01 GM042539 / NIGMS NIH HHS R21 AR060012 / NIAMS NIH HHS R01 GM061513 / NIGMS NIH HHS AR060012 / NIAMS NIH HHS
Language: English
Date published: 06/2011
Academic Unit: Obstetrics and Gynecology; Biochemistry and Molecular Biology; University College Courses
Record Identifier: 9984025395602771

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