Journal article
Nuclear warfare: pathogen manipulation of the nuclear pore complex and nuclear functions
mBio, Vol.16(4), e01940-24
04/09/2025
DOI: 10.1128/mbio.01940-24
PMCID: PMC11980394
PMID: 40111017
Abstract
Viruses and bacteria exploit the nuclear pore complex (NPC) and host nuclear functions to bypass cellular barriers and manipulate essential processes. Viruses frequently engage directly with NPC components, such as nucleoporins, to enable genome import and evade immune defenses. In contrast, bacterial pathogens rely on secreted effector proteins to disrupt nuclear transport and reprogram host transcription. These strategies reflect a remarkable evolutionary convergence, with both types of pathogens targeting the NPC and nuclear functions to promote infection. This minireview explores the overlapping and unique mechanisms by which pathogens hijack the host nucleus, shedding light on their roles in disease and potential avenues for therapeutic intervention.
Details
- Title: Subtitle
- Nuclear warfare: pathogen manipulation of the nuclear pore complex and nuclear functions
- Creators
- Brianna Steiert - University of IowaMary M. Weber - University of Iowa
- Contributors
- Jacob Yount (Editor)
- Resource Type
- Journal article
- Publication Details
- mBio, Vol.16(4), e01940-24
- DOI
- 10.1128/mbio.01940-24
- PMID
- 40111017
- PMCID
- PMC11980394
- NLM abbreviation
- mBio
- ISSN
- 2150-7511
- eISSN
- 2150-7511
- Publisher
- American Society for Microbiology
- Number of pages
- 18
- Grant note
- NIH: R01 AI150812, R01 AI155434, R61 AI179999, T32 AI007511 University of Iowa Stead Family Scholars
We acknowledge grant support from the NIH (M.M.W., R01 AI150812, R01 AI155434, and R61 AI179999; B.S. T32 AI007511) and the University of Iowa Stead Family Scholars to M.M.W.
- Language
- English
- Electronic publication date
- 03/20/2025
- Date published
- 04/09/2025
- Academic Unit
- Molecular Physiology and Biophysics; Microbiology and Immunology
- Record Identifier
- 9984801839202771
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