Journal article
Nucleosome positioning and gene regulation
Journal of cellular biochemistry, Vol.55(1), pp.83-92
05/1994
DOI: 10.1002/jcb.240550110
PMID: 8083303
Abstract
Recent genetic and biochemical studies have revealed critical information concerning the role of nucleosomes in eukaryotic gene regulation. Nucleosomes package DNA into a dynamic chromatin structure, and by assuming defined positions in chromatin, influence gene regulation. Nucleosomes can serve as repressors, presumably by blocking access to regulatory elements; consequently, the positions of nucleosomes relative to the location of cis‐acting elements are critical. Some genes have a chromatin structure that is “preset,” ready for activation, while others require “remodeling” for activation. Nucleosome positioning may be determined by multiple factors, including histone–DNA interactions, boundaries defined by DNA structure or protein binding, and higher‐order chromatin structure. © 1994 Wiley‐Liss, Inc.
Details
- Title: Subtitle
- Nucleosome positioning and gene regulation
- Creators
- Quinn LuLori L WallrathSarah C. R Elgin
- Resource Type
- Journal article
- Publication Details
- Journal of cellular biochemistry, Vol.55(1), pp.83-92
- DOI
- 10.1002/jcb.240550110
- PMID
- 8083303
- NLM abbreviation
- J Cell Biochem
- ISSN
- 0730-2312
- eISSN
- 1097-4644
- Publisher
- Wiley Subscription Services, Inc., A Wiley Company; Hoboken
- Number of pages
- 10
- Language
- English
- Date published
- 05/1994
- Academic Unit
- Biochemistry and Molecular Biology; University College Courses
- Record Identifier
- 9984025271002771
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