Number of prior live births is associated with higher arterial stiffness but not its change in older women: the atherosclerosis risk in communities study

Alison N. Bonner; Shantal Jayawickreme; Angela M. Malek; Catherine J. Vladutiu; Clare Oliver-Williams; Yamnia I. Cortes; Hirofumi Tanaka; Michelle L. Meyer

doi:10.3389/fcvm.2023.1172828

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Number of prior live births is associated with higher arterial stiffness but not its change in older women: the atherosclerosis risk in communities study

Journal article

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Number of prior live births is associated with higher arterial stiffness but not its change in older women: the atherosclerosis risk in communities study

Alison N. Bonner, Shantal Jayawickreme, Angela M. Malek, Catherine J. Vladutiu, Clare Oliver-Williams, Yamnia I. Cortes, Hirofumi Tanaka and Michelle L. Meyer

Frontiers in cardiovascular medicine, Vol.10, pp.1172828-1172828

05/23/2023

DOI: 10.3389/fcvm.2023.1172828

PMCID: PMC10242178

PMID: 37288258

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Abstract

IntroductionAlthough studies have demonstrated a J-shaped association between parity and cardiovascular disease (CVD), the association with arterial stiffness is not fully understood. MethodsWe examined the association between parity and carotid-femoral pulse wave velocity (cfPWV), a measure of central arterial stiffness. We conducted a longitudinal analysis of 1220 women (mean age 73.7 years) who attended the Atherosclerosis Risk in Communities Study visit 5 (2011-2013). At visit 2 (1990-1992), women self-reported parity (number of prior live births), which we categorized as: 0 (never pregnant or pregnant with no live births); 1-2 (referent); 3-4; and 5+ live births. Technicians measured cfPWV at visit 5 (2011-2013) and visit 6 or 7 (2016-2019). Multivariable linear regression modeled the associations of parity with visit 5 cfPWV and cfPWV change between visit 5 and 6/7 adjusted for demographics and potential confounding factors. ResultsParticipants reported 0 (7.7%), 1-2 (38.7%), 3-4 (40.0%), or 5+ (13.6%) prior live births. In adjusted analyses, women with 5+ live births had a higher visit 5 cfPWV (beta=50.6 cm/s, 95% confidence interval: 3.6, 97.7 cm/s) than those with 1-2 live births. No statistically significant associations were observed for other parity groups with visit 5 cfPWV or with cfPWV change. DiscussionIn later life, women with 5+ live births had higher arterial stiffness than those with 1-2 live births, but cfPWV change did not differ by parity, suggesting women with 5+ live births should be targeted for early primary prevention of CVD given their higher arterial stiffness at later-life.

Cardiac & Cardiovascular Systems

Cardiovascular System & Cardiology

Life Sciences & Biomedicine

Science & Technology

Details

Title: Subtitle: Number of prior live births is associated with higher arterial stiffness but not its change in older women: the atherosclerosis risk in communities study
Creators: Alison N. Bonner - University of North Carolina at Chapel Hill
Shantal Jayawickreme - University of North Carolina at Chapel Hill
Angela M. Malek - Medical University of South Carolina
Catherine J. Vladutiu - University of North Carolina at Chapel Hill
Clare Oliver-Williams - University of Leicester
Yamnia I. Cortes - University of North Carolina at Chapel Hill
Hirofumi Tanaka - The University of Texas at Austin
Michelle L. Meyer - University of North Carolina at Chapel Hill
Resource Type: Journal article
Publication Details: Frontiers in cardiovascular medicine, Vol.10, pp.1172828-1172828
DOI: 10.3389/fcvm.2023.1172828
PMID: 37288258
PMCID: PMC10242178
NLM abbreviation: Front Cardiovasc Med
ISSN: 2297-055X
eISSN: 2297-055X
Publisher: Frontiers Media Sa
Number of pages: 8
Grant note: award: HHSN268201700001I, HHSN268201700002I, HHSN268201700003I, HHSN268201700005I, HHSN268201700004I, R01AG053938, T35-HL134624; DOI: 10.13039/100000050, name: National Heart, Lung, and Blood Institute, award: R01AG062488, R01AG061088; DOI: 10.13039/100000049, name: National Institute on Aging
Language: English
Date published: 05/23/2023
Academic Unit: Nursing
Record Identifier: 9984446404002771

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