Nutraceuticals against Neurodegeneration: A Mechanistic Insight

Vivekkumar P Dadhania; Priyanka P Trivedi; Ajit Vikram; Durga Nand Tripathi

doi:10.2174/1570159X14666160104142223

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Nutraceuticals against Neurodegeneration: A Mechanistic Insight

Journal article

Open access

Peer reviewed

Nutraceuticals against Neurodegeneration: A Mechanistic Insight

Vivekkumar P Dadhania, Priyanka P Trivedi, Ajit Vikram and Durga Nand Tripathi

Current neuropharmacology, Vol.14(6), pp.627-640

2016

DOI: 10.2174/1570159X14666160104142223

PMCID: PMC4981739

PMID: 26725888

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https://europepmc.org/articles/pmc4981739View

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Abstract

The mechanisms underlying neurodegenerative disorders are complex and multifactorial; however, accumulating evidences suggest few common shared pathways. These common pathways include mitochondrial dysfunction, intracellular Ca2+ overload, oxidative stress and inflammation. Often multiple pathways co-exist, and therefore limit the benefits of therapeutic interventions. Nutraceuticals have recently gained importance owing to their multifaceted effects. These food-based approaches are believed to target multiple pathways in a slow but more physiological manner without causing severe adverse effects. Available information strongly supports the notion that apart from preventing the onset of neuronal damage, nutraceuticals can potentially attenuate the continued progression of neuronal destruction. In this article, we i) review the common pathways involved in the pathogenesis of the toxicants-induced neurotoxicity and neurodegenerative disorders with special emphasis on Alzheimer`s disease (AD), Parkinson`s disease (PD), Huntington`s disease (HD), Multiple sclerosis (MS) and Amyotrophic lateral sclerosis (ALS), and ii) summarize current research advancements on the effects of nutraceuticals against these detrimental pathways.

Animals

Dietary Supplements

Humans

Neurodegenerative Diseases - diet therapy

Neurodegenerative Diseases - metabolism

Details

Title: Subtitle: Nutraceuticals against Neurodegeneration: A Mechanistic Insight
Creators: Vivekkumar P Dadhania
Priyanka P Trivedi
Ajit Vikram - University of Iowa
Durga Nand Tripathi - Texas A&M Health Science Center
Resource Type: Journal article
Publication Details: Current neuropharmacology, Vol.14(6), pp.627-640
DOI: 10.2174/1570159X14666160104142223
PMID: 26725888
PMCID: PMC4981739
NLM abbreviation: Curr Neuropharmacol
ISSN: 1570-159X
eISSN: 1875-6190
Language: English
Date published: 2016
Academic Unit: Cardiovascular Medicine; Fraternal Order of Eagles Diabetes Research Center; Internal Medicine
Record Identifier: 9984359874602771

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