Journal article
Nutrient intakes in women and risks of anophthalmia and microphthalmia in their offspring
Birth Defects Research Part A: Clinical and Molecular Teratology, Vol.66(6), pp.708-713
10/2007
DOI: 10.1002/bdra.20398
PMID: 17847120
Abstract
BACKGROUND There is a paucity of information about risk factors for the human eye anomalies anophthalmia and microphthalmia. In this population-based case-control study we investigated whether periconceptional intakes of supplemental folic acid, dietary folate, vitamin A, and several other nutrients were associated with these eye defects. METHODS This study included data on deliveries that had estimated due dates from 1997–2002 and were part of the National Birth Defects Prevention Study (the National Birth Defects Prevention Study is a population-based case-control study of a wide spectrum of birth defects, incorporating data from 10 birth defects surveillance systems in the United States [Arkansas, California, Georgia/Centers for Disease Control and Prevention, Iowa, Massachusetts, New Jersey, New York, North Carolina, Texas, and Utah]). Cases were those infants or fetuses born with either anophthalmia or microphthalmia. Liveborn infants without major malformations were eligible as controls. Maternal interviews were conducted, primarily by telephone, in English or Spanish. Participation in the interview was 71% among case mothers and 68% among control mothers. Interviews were completed with 89 case mothers and 4,143 control mothers. A shortened version of the food frequency questionnaire from the Nurse's Health Study was used to assess frequency of intake of 58 food items during the year before pregnancy. RESULTS Our results did not indicate reduced risks for these eye malformations associated with maternal intake of vitamin supplements containing folic acid. The data did not show an association between malformation risk and higher or lower intakes of vitamin A. We also did not observe strong evidence that an abundance or a lack of dietary intake of any other nutrient was associated with increased risk of the studied eye malformations. CONCLUSIONS Our observations contribute to a limited body of findings on these rare eye defects.
Details
- Title: Subtitle
- Nutrient intakes in women and risks of anophthalmia and microphthalmia in their offspring
- Creators
- Gary M Shaw - March of Dimes Birth Defects Foundation, California Research Division, Oakland, CaliforniaSuzan L Carmichael - March of Dimes Birth Defects Foundation, California Research Division, Oakland, CaliforniaCecile Laurent - March of Dimes Birth Defects Foundation, California Research Division, Oakland, CaliforniaCarol Louik - Slone Epidemiology Unit, Boston, MassachusettsRichard H Finnell - Institute of Biosciences and Technology, Houston, TexasEdward J Lammer - Children's Hospital Oakland Research Institute, Oakland, CaliforniaNational Birth Defects Prevention Study
- Contributors
- Paul A Romitti (Contributor) - University of Iowa, Epidemiology
- Resource Type
- Journal article
- Publication Details
- Birth Defects Research Part A: Clinical and Molecular Teratology, Vol.66(6), pp.708-713
- Publisher
- Wiley Subscription Services, Inc., A Wiley Company
- DOI
- 10.1002/bdra.20398
- PMID
- 17847120
- ISSN
- 1542-0752
- eISSN
- 1096-9926
- Number of pages
- 6
- Language
- English
- Date published
- 10/2007
- Academic Unit
- Epidemiology; Biostatistics
- Record Identifier
- 9984214719102771
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