Journal article
Nutrition and Nutraceuticals in Neuroinflammatory and Brain Metabolic Stress: Implications for Neurodegenerative Disorders
CNS & neurological disorders drug targets, Vol.17(9), pp.680-688
2018
DOI: 10.2174/1871527317666180625104753
PMID: 29938622
Abstract
A steep rise in the incidences of neurodegenerative disorders could be the combined effect of several non-genetic factors such as increased life expectancy, environmental pollutants, lifestyle, and dietary habits, as population-level genetic change require multiple generations. Emerging evidence suggests that chronic over-nutrition induces brain metabolic stress and neuroinflammation, and are individually known to promote neurodegenerative disorders including Alzheimer's disease (AD), Parkinson's disease (PD) and Huntington's disease (HD). Although the association of metabolic disorders such as diabetes, hypertension, dyslipidemia, and atherosclerosis with the dietary habits is well known, neuronal implications of diet and nutritional factors is still in its infancy. Transcriptomics and proteomics-based studies support the view that nutraceuticals target multiple neuroprotective pathways in a slow but effective manner without causing severe adverse effects, and may represent the future of tackling neurodegenerative disorders.
In this article we i) review the diet/dietary supplement connection with brain metabolic stress and neuroinflammation and ii) summarize current knowledge of the effects of nutraceuticals on neurodegenerative disorders.
Details
- Title: Subtitle
- Nutrition and Nutraceuticals in Neuroinflammatory and Brain Metabolic Stress: Implications for Neurodegenerative Disorders
- Creators
- M D Pandareesh - Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, New York-10314, United StatesHemanth Kumar Kandikattu - Department of Internal Medicine, The University of Missouri, Columbia-65201, Missouri, United StatesSakina Razack - Department of Biochemistry, University of Mysore, Manasagangotri, Karnataka, IndiaNarayanappa Amruta - Department of Internal Medicine, The University of Missouri, Columbia-65201, Missouri, United StatesRamesh Choudhari - Department of Biomedical Sciences, Texas Tech University, Health Sciences Center, El Paso 79905, United StatesAjit Vikram - Department of Internal Medicine, University of Iowa, Iowa City, 52242, IA, United StatesPrakash Doddapattar - Department of Internal Medicine, University of Iowa, Iowa City, 52242, IA, United States
- Resource Type
- Journal article
- Publication Details
- CNS & neurological disorders drug targets, Vol.17(9), pp.680-688
- DOI
- 10.2174/1871527317666180625104753
- PMID
- 29938622
- ISSN
- 1871-5273
- eISSN
- 1996-3181
- Language
- English
- Date published
- 2018
- Academic Unit
- Hematology, Oncology, and Blood & Marrow Transplantation; Cardiovascular Medicine; Fraternal Order of Eagles Diabetes Research Center; Internal Medicine
- Record Identifier
- 9984094521902771
Metrics
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