Journal article
Nutrition in congenital diaphragmatic hernia: How and when?
Seminars in fetal & neonatal medicine, Vol.30(3), 101650
10/2025
DOI: 10.1016/j.siny.2025.101650
PMID: 40615337
Abstract
Survival for infants with congenital diaphragmatic hernia (CDH) has improved, but they continue to face significant nutritional morbidity. They are at risk of growth failure, malnutrition, gastroesophageal reflux disease (GERD), oral aversion, and the need for nutritional tube feeding support after the initial hospitalization. Malnutrition and poor nutritional outcomes impact neurodevelopment, underlining the importance of addressing these issues. Available evidence in this area is scarce, and controversies remain about the timing and mode of enteral feeding in the peri-operative period, the role of enteral nutrition on extracorporeal membrane oxygenation (ECMO), and nutritional growth targets for infants with CDH.
In this manuscript, we discuss enteral and parenteral targets for infants with CDH, growth targets, the timing and advancement of enteral feeding. In addition, we discuss post-discharge nutritional support, identify gaps in the current literature and address parental concerns around nutrition and growth in infants with CDH.
[Display omitted]
•Infants with CDH are at risk for significant nutritional morbidity.•Early and appropriate nutrition may help to mitigate growth failure and malnutrition.•Parenteral nutrition is the standard of care pre-repair but new data suggests the safety of enteral nutrition pre-repair.•Discharge planning and long-term follow-up are key to improving outcomes in survivors of CDH.
Details
- Title: Subtitle
- Nutrition in congenital diaphragmatic hernia: How and when?
- Creators
- Ulla Lei Larsen - University of Southern DenmarkJohn T. Wren - University of Iowa Health CareChristy Gilcrease - St. Louis Children's HospitalMark Bremholm Ellebaek - University of Southern DenmarkPatrick E. Sloan - Washington University in St. Louis
- Resource Type
- Journal article
- Publication Details
- Seminars in fetal & neonatal medicine, Vol.30(3), 101650
- DOI
- 10.1016/j.siny.2025.101650
- PMID
- 40615337
- NLM abbreviation
- Semin Fetal Neonatal Med
- ISSN
- 1744-165X
- eISSN
- 1878-0946
- Publisher
- Elsevier Ltd; London
- Language
- English
- Electronic publication date
- 07/01/2025
- Date published
- 10/2025
- Academic Unit
- Stead Family Department of Pediatrics; Neonatology
- Record Identifier
- 9984848017702771
Metrics
2 Record Views