Journal article
Nutritional factors and hypospadias risks
Paediatric and perinatal epidemiology, Vol.26(4), pp.353-360
07/2012
DOI: 10.1111/j.1365-3016.2012.01272.x
PMCID: PMC3376012
PMID: 22686387
Abstract
We examined whether hypospadias was associated with several aspects of the diet, including intake of animal products, intake of several nutrients and food groups related to a vegetarian diet and estrogen metabolism, and diet quality. The study included deliveries from 1997 to 2005 that were part of the National Birth Defects Prevention Study. Diet was assessed by food frequency questionnaire during maternal telephone interviews, and two diet quality indices were developed based on existing indices. Analyses included 1,250 cases with second or third degree hypospadias (urethra opened at the penile shaft, scrotum or perineum) and 3,118 male, liveborn, non-malformed controls. All odds ratios (ORs) and 95% confidence intervals (CI) were estimated from logistic regression models that included several potential confounders, including energy intake. Intake of animal products was not associated with hypospadias; e.g., the adjusted OR for any versus no intake of meat was 1.0 (95% CI 0.6, 1.6). Frequency of intake of meat or other animal products was also not associated with hypospadias, nor was intake of iron or several nutrients that are potentially related to estrogen metabolism. Diet quality was also not associated with hypospadias; the ORs for diet quality in the highest versus lowest quartile for the two diet quality indices were 1.0 (95% CI 0.6, 1.6) and 0.9 (95% CI 0.7, 1.1). In conclusion, this large study does not support an association of a vegetarian diet or worse diet quality with hypospadias.
Details
- Title: Subtitle
- Nutritional factors and hypospadias risks
- Creators
- Suzan L Carmichael - Department of Pediatrics, Stanford University, Stanford, CA Division of Medical Genetics, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, UT Utah Birth Defect Network, Utah Department of Health, Salt Lake City, UT Department of Nutrition, Dietetics and Food Sciences, Utah State University, Logan, UT National Center on Birth Defects and Developmental Disabilities, CDC, Atlanta, GAChen Ma - Department of Pediatrics, Stanford University, Stanford, CA Division of Medical Genetics, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, UT Utah Birth Defect Network, Utah Department of Health, Salt Lake City, UT Department of Nutrition, Dietetics and Food Sciences, Utah State University, Logan, UT National Center on Birth Defects and Developmental Disabilities, CDC, Atlanta, GAMarcia L Feldkamp - Department of Pediatrics, Stanford University, Stanford, CA Division of Medical Genetics, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, UT Utah Birth Defect Network, Utah Department of Health, Salt Lake City, UT Department of Nutrition, Dietetics and Food Sciences, Utah State University, Logan, UT National Center on Birth Defects and Developmental Disabilities, CDC, Atlanta, GARonald G Munger - Department of Pediatrics, Stanford University, Stanford, CA Division of Medical Genetics, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, UT Utah Birth Defect Network, Utah Department of Health, Salt Lake City, UT Department of Nutrition, Dietetics and Food Sciences, Utah State University, Logan, UT National Center on Birth Defects and Developmental Disabilities, CDC, Atlanta, GARichard S Olney - Department of Pediatrics, Stanford University, Stanford, CA Division of Medical Genetics, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, UT Utah Birth Defect Network, Utah Department of Health, Salt Lake City, UT Department of Nutrition, Dietetics and Food Sciences, Utah State University, Logan, UT National Center on Birth Defects and Developmental Disabilities, CDC, Atlanta, GALorenzo D Botto - Department of Pediatrics, Stanford University, Stanford, CA Division of Medical Genetics, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, UT Utah Birth Defect Network, Utah Department of Health, Salt Lake City, UT Department of Nutrition, Dietetics and Food Sciences, Utah State University, Logan, UT National Center on Birth Defects and Developmental Disabilities, CDC, Atlanta, GAGary M Shaw - Department of Pediatrics, Stanford University, Stanford, CA Division of Medical Genetics, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, UT Utah Birth Defect Network, Utah Department of Health, Salt Lake City, UT Department of Nutrition, Dietetics and Food Sciences, Utah State University, Logan, UT National Center on Birth Defects and Developmental Disabilities, CDC, Atlanta, GAAdolfo Correa - Department of Pediatrics, Stanford University, Stanford, CA Division of Medical Genetics, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, UT Utah Birth Defect Network, Utah Department of Health, Salt Lake City, UT Department of Nutrition, Dietetics and Food Sciences, Utah State University, Logan, UT National Center on Birth Defects and Developmental Disabilities, CDC, Atlanta, GANational Birth Defects Prevention Study
- Contributors
- Paul A Romitti (Contributor) - University of Iowa, Epidemiology
- Resource Type
- Journal article
- Publication Details
- Paediatric and perinatal epidemiology, Vol.26(4), pp.353-360
- DOI
- 10.1111/j.1365-3016.2012.01272.x
- PMID
- 22686387
- PMCID
- PMC3376012
- NLM abbreviation
- Paediatr Perinat Epidemiol
- ISSN
- 0269-5022
- eISSN
- 1365-3016
- Grant note
- R03 HD058873-01 || HD / National Institute of Child Health & Human Development : NICHD
- Language
- English
- Date published
- 07/2012
- Academic Unit
- Epidemiology; Biostatistics
- Record Identifier
- 9984214839302771
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