Journal article
Nutritional immunity beyond iron: a role for manganese and zinc
Current opinion in chemical biology, Vol.14(2), pp.218-224
04/01/2010
DOI: 10.1016/j.cbpa.2009.11.008
PMCID: PMC2847644
PMID: 20015678
Abstract
Vertebrates sequester iron from invading pathogens, and conversely, pathogens express a variety of factors to steal iron from the host. Recent work has demonstrated that in addition to iron, vertebrates sequester zinc and manganese both intracellularly and extracellularly to protect against infection. Intracellularly, vertebrates utilize the ZIP/ZnT families of transporters to manipulate zinc levels, as well as Nramp1 to manipulate manganese levels Extracellularly, the S100 protein calprotectin sequesters manganese and potentially zinc to inhibit microbial growth To circumvent these defenses, bacteria possess high affinity transporters to import specific nutrient metals. Limiting the availability of zinc and manganese as a mechanism to defend against infection expands the spectrum of nutritional immunity and further establishes metal sequestration as a key defense against microbial invaders
Details
- Title: Subtitle
- Nutritional immunity beyond iron: a role for manganese and zinc
- Creators
- Thomas E. Kehl-Fie - Vanderbilt University Medical CenterEric P. Skaar - Vanderbilt University Medical Center
- Resource Type
- Journal article
- Publication Details
- Current opinion in chemical biology, Vol.14(2), pp.218-224
- Publisher
- Elsevier
- DOI
- 10.1016/j.cbpa.2009.11.008
- PMID
- 20015678
- PMCID
- PMC2847644
- ISSN
- 1367-5931
- eISSN
- 1879-0402
- Number of pages
- 7
- Grant note
- Southeastern Regional Center of Excellence for Emerging Infections and Biodefense; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID) U154 A1057157 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA R01AI073843 / NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID) A1069233; A1073843; T32 HL094296-02 / NIAID; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID) T32HL094296 / NATIONAL HEART, LUNG, AND BLOOD INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI)
- Language
- English
- Date published
- 04/01/2010
- Academic Unit
- Microbiology and Immunology
- Record Identifier
- 9984618513402771
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