Journal article
Nystagmus and saccadic intrusions
Handbook of clinical neurology, Vol.102, pp.333-378
2011
DOI: 10.1016/B978-0-444-52903-9.00019-4
PMID: 21601073
Abstract
We review current concepts of nystagmus and saccadic oscillations, applying a pathophysiological approach. We begin by discussing how nystagmus may arise when the mechanisms that normally hold gaze steady are impaired. We then describe the clinical and laboratory evaluation of patients with ocular oscillations. Next, we systematically review the features of nystagmus arising from peripheral and central vestibular disorders, nystagmus due to an abnormal gaze-holding mechanism (neural integrator), and nystagmus occurring when vision is compromised. We then discuss forms of nystagmus for which the pathogenesis is not well understood, including acquired pendular nystagmus and congenital forms of nystagmus. We then summarize the spectrum of saccadic disorders that disrupt steady gaze, from intrusions to flutter and opsoclonus. Finally, we review current treatment options for nystagmus and saccadic oscillations, including drugs, surgery, and optical methods. Examples of each type of nystagmus are provided in the form of figures.
Details
- Title: Subtitle
- Nystagmus and saccadic intrusions
- Creators
- Matthew J Thurtell - Departments of Neurology and Daroff-Dell'Osso Laboratory, Veterans Affairs Medical Center and University Hospitals, Case Western Reserve University, Cleveland, OH 44106, USAR John Leigh
- Resource Type
- Journal article
- Publication Details
- Handbook of clinical neurology, Vol.102, pp.333-378
- Publisher
- Netherlands
- DOI
- 10.1016/B978-0-444-52903-9.00019-4
- PMID
- 21601073
- ISSN
- 0072-9752
- Language
- English
- Date published
- 2011
- Academic Unit
- Neurology; Ophthalmology and Visual Sciences
- Record Identifier
- 9983980291202771
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