Obesity Does Not Exacerbate the Protumorigenic Systemic Environment in Sarcoma Subjects

Claire M Buchta; Shannon K Boi; Benjamin J Miller; Mohammed M Milhem; Lyse A Norian

doi:10.4049/immunohorizons.1700001

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Obesity Does Not Exacerbate the Protumorigenic Systemic Environment in Sarcoma Subjects

Journal article

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Obesity Does Not Exacerbate the Protumorigenic Systemic Environment in Sarcoma Subjects

Claire M Buchta, Shannon K Boi, Benjamin J Miller, Mohammed M Milhem and Lyse A Norian

ImmunoHorizons, Vol.1(4), pp.20-28

06/01/2017

DOI: 10.4049/immunohorizons.1700001

PMCID: PMC5711445

PMID: 29202127

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https://doi.org/10.4049/immunohorizons.1700001View

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Abstract

Sarcomas are a rare but fatal tumor type that accounts for <1% of adult solid malignancies and ~15% of childhood malignancies. Although the use of immunotherapy is being actively investigated for other solid tumors, advances in immunotherapy for sarcoma patients are lacking. To better understand the systemic immune environment in sarcoma patients, we performed a detailed multiplex analysis of serum cytokines, chemokines, and protumorigenic factors from treatment-naive subjects with localized, high-grade sarcoma. Because obesity is a major healthcare issue in the United States, we additionally examined the effects of obesity on serum protein profiles in our sarcoma subject cohort. We found that the systemic host environment is profoundly altered to favor tumor progression, with epidermal growth factor, angiopoietin-2, vascular endothelial growth factor A, IL-6, IL-8, and MIP-1β all increased relative to tumor-free controls (all < 0.05). Surprisingly, we found that obesity did not exacerbate this protumorigenic profile, as epidermal growth factor and IL-8 decreased with increasing subject body mass index (both < 0.05 versus normal or overweight subjects). The Th2-related cytokines IL-4, IL-5, and IL-13 were also decreased in the presence of obesity. Thus, although the systemic environment in sarcoma subjects favors tumor progression, obesity does not further aggravate the production of protumorigenic factors.

Details

Title: Subtitle: Obesity Does Not Exacerbate the Protumorigenic Systemic Environment in Sarcoma Subjects
Creators: Claire M Buchta - Department of Urology, University of Iowa, Iowa City, IA 52242
Shannon K Boi - Graduate Biomedical Sciences, Immunology Theme, University of Alabama at Birmingham, Birmingham, AL 35233
Benjamin J Miller - Department of Orthopaedics and Rehabilitation, University of Iowa, Iowa City, IA 52242
Mohammed M Milhem - Division of Hematology and Oncology, University of Iowa, Iowa City, IA 52242
Lyse A Norian - Department of Nutrition Sciences, Nutrition Obesity Research Center, and Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, AL 35233
Resource Type: Journal article
Publication Details: ImmunoHorizons, Vol.1(4), pp.20-28
DOI: 10.4049/immunohorizons.1700001
PMID: 29202127
PMCID: PMC5711445
NLM abbreviation: Immunohorizons
ISSN: 2573-7732
eISSN: 2573-7732
Publisher: United States
Grant note: T32 AI007051 / NIAID NIH HHS R25 CA047888 / NCI NIH HHS R01 CA181088 / NCI NIH HHS
Language: English
Date published: 06/01/2017
Academic Unit: Hematology, Oncology, and Blood & Marrow Transplantation; Orthopedics and Rehabilitation; Internal Medicine
Record Identifier: 9984040485002771

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