Journal article
Obesity Hypertension: Pathophysiological Role of Leptin in Neuroendocrine Dysregulation
The American journal of the medical sciences, Vol.347(6), pp.485-489
06/01/2014
DOI: 10.1097/MAJ.0b013e31827ad5cf
PMID: 23426087
Abstract
Leptin is a 16-kDa peptide hormone that is primarily synthesized and secreted by adipose tissue. One of the major actions of this hormone is the control of energy balance by binding to receptors in the hypothalamus, leading to reduction in food intake, elevation in temperature and energy expenditure. In addition, increasing evidence suggests that leptin, through both direct and indirect mechanisms, may play an important role in cardiovascular and renal regulation. Although the relevance of endogenous leptin needs further clarification, it appears to function as a pressure- and volume-regulating factor under conditions of health. However, in abnormal situations characterized by chronic hyperleptinemia such as obesity, it may function pathophysiologically for the development of hypertension and possibly also for direct renal, vascular and cardiac damage.
Details
- Title: Subtitle
- Obesity Hypertension: Pathophysiological Role of Leptin in Neuroendocrine Dysregulation
- Creators
- Orson Go - SUNY Upstate Medical UniversityRonald H. Freeman - University of MissouriGarry P. Reams - University of MissouriRobert Spear - SUNY Upstate Medical UniversityKan Liu - SUNY Upstate Medical UniversityDaniel Villarreal - SUNY Upstate Medical University
- Resource Type
- Journal article
- Publication Details
- The American journal of the medical sciences, Vol.347(6), pp.485-489
- Publisher
- Elsevier
- DOI
- 10.1097/MAJ.0b013e31827ad5cf
- PMID
- 23426087
- ISSN
- 0002-9629
- eISSN
- 1538-2990
- Number of pages
- 5
- Grant note
- Joseph C. George Research Award Hendricks Research Award Veteran Affairs Research Program (Merit Review)
- Language
- English
- Date published
- 06/01/2014
- Academic Unit
- Radiology; Cardiovascular Medicine; Internal Medicine
- Record Identifier
- 9984318707602771
Metrics
6 Record Views