Obesity Hypertension: The Regulatory Role of Leptin

Shilpa Kshatriya; Kan Liu; Ali Salah; Tamas Szombathy; Ronald H. Freeman; Garry P. Reams; Robert M. Spear; Daniel Villarreal

doi:10.4061/2011/270624

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Obesity Hypertension: The Regulatory Role of Leptin

Journal article

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Peer reviewed

Obesity Hypertension: The Regulatory Role of Leptin

Shilpa Kshatriya, Kan Liu, Ali Salah, Tamas Szombathy, Ronald H. Freeman, Garry P. Reams, Robert M. Spear and Daniel Villarreal

International journal of hypertension, Vol.2011, pp.270624-8

01/03/2011

DOI: 10.4061/2011/270624

PMCID: PMC3022168

PMID: 21253519

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Abstract

Leptin is a 16-kDa-peptide hormone that is primarily synthesized and secreted by adipose tissue. One of the major actions of this hormone is the control of energy balance by binding to receptors in the hypothalamus, leading to reduction in food intake and elevation in temperature and energy expenditure. In addition, increasing evidence suggests that leptin, through both direct and indirect mechanisms, may play an important role in cardiovascular and renal regulation. While the relevance of endogenous leptin needs further clarification, it appears to function as a pressure and volume-regulating factor under conditions of health. However, in abnormal situations characterized by chronic hyperleptinemia such as obesity, it may function pathophysiologically for the development of hypertension and possibly also for direct renal, vascular, and cardiac damage.

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Title: Subtitle: Obesity Hypertension: The Regulatory Role of Leptin
Creators: Shilpa Kshatriya - SUNY Upstate Medical University
Kan Liu - SUNY Upstate Medical University
Ali Salah - SUNY Upstate Medical University
Tamas Szombathy - SUNY Upstate Medical University
Ronald H. Freeman - University of Missouri
Garry P. Reams - University of Missouri
Robert M. Spear - SUNY Upstate Medical University
Daniel Villarreal - SUNY Upstate Medical University
Resource Type: Journal article
Publication Details: International journal of hypertension, Vol.2011, pp.270624-8
DOI: 10.4061/2011/270624
PMID: 21253519
PMCID: PMC3022168
NLM abbreviation: Int J Hypertens
ISSN: 2090-0392
eISSN: 2090-0392
Publisher: SAGE-Hindawi Access to Research
Grant note: name: Veteran Affairs Research Program
Language: English
Date published: 01/03/2011
Academic Unit: Radiology; Cardiovascular Medicine; Internal Medicine
Record Identifier: 9984318799802771

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