Journal article
Obesity, Smoking, and Frontal Brain Dysfunction
The American journal on addictions, Vol.19(5), pp.391-400
09/2010
DOI: 10.1111/j.1521-0391.2010.00069.x
PMCID: PMC2924769
PMID: 20716301
Abstract
Obesity, smoking, and conduct problems have all been associated with decrements in brain function. However, their additive and interactive effects have rarely been examined. To address the deficiency, we studied P300a and P300b electroencephalographic potentials in 218 women grouped by the presence versus absence of: (
1
) a BMI ≥30 kg/m
2
; (
2
) recent smoking; and (
3
) ≥2 childhood conduct problems. Analyses revealed smaller P300a and P300b amplitudes over the posterior scalp among recent smokers versus nonsmokers. No corresponding group differences were found in P300 latencies or frontal scalp amplitudes. The most interesting analysis result was an interaction between conduct problems and obesity limited to the frontally-generated P300a component: its latency was significantly greater in women with both attributes than in those with either or neither attribute. An exploratory ANOVA, substituting the genotype of a
GABRA2
SNP for conduct problems, also demonstrated the interaction. It is hypothesized that conduct problems, and a conduct-problem-associated
GABRA2
genotype, decrease the age-of-onset and/or increase the lifetime duration of obesity. As a result, they may potentiate the adverse effects of obesity on frontal white matter and thereby increase P300a latency. Smoking may affect brain function by a different mechanism to reduce posterior scalp P300a and P300b amplitudes while preserving frontal scalp P300a latency and amplitude.
Details
- Title: Subtitle
- Obesity, Smoking, and Frontal Brain Dysfunction
- Creators
- Lance Bauer - Department of Psychiatry, SUNY Downstate Medical Center, Brooklyn, NY, USADanielle Dick - Department of Psychiatry, SUNY Downstate Medical Center, Brooklyn, NY, USALaura Bierut - Department of Psychiatry, SUNY Downstate Medical Center, Brooklyn, NY, USAKathleen Bucholz - Department of Psychiatry, SUNY Downstate Medical Center, Brooklyn, NY, USAHoward Edenberg - Department of Psychiatry, SUNY Downstate Medical Center, Brooklyn, NY, USASamuel Kuperman - Department of Psychiatry, SUNY Downstate Medical Center, Brooklyn, NY, USAJohn Kramer - Department of Psychiatry, SUNY Downstate Medical Center, Brooklyn, NY, USAJohn Nurnberger - Department of Psychiatry, SUNY Downstate Medical Center, Brooklyn, NY, USASean O’Connor - Department of Psychiatry, SUNY Downstate Medical Center, Brooklyn, NY, USAJohn Rice - Department of Psychiatry, SUNY Downstate Medical Center, Brooklyn, NY, USAJohn Rohrbaugh - Department of Psychiatry, SUNY Downstate Medical Center, Brooklyn, NY, USAMarc Schuckit - Department of Psychiatry, SUNY Downstate Medical Center, Brooklyn, NY, USAJay Tischfield - Department of Psychiatry, SUNY Downstate Medical Center, Brooklyn, NY, USABernice Porjesz - Department of Psychiatry, SUNY Downstate Medical Center, Brooklyn, NY, USAVictor Hesselbrock - Department of Psychiatry, SUNY Downstate Medical Center, Brooklyn, NY, USA
- Resource Type
- Journal article
- Publication Details
- The American journal on addictions, Vol.19(5), pp.391-400
- DOI
- 10.1111/j.1521-0391.2010.00069.x
- PMID
- 20716301
- PMCID
- PMC2924769
- NLM abbreviation
- Am J Addict
- ISSN
- 1055-0496
- eISSN
- 1521-0391
- Language
- English
- Date published
- 09/2010
- Academic Unit
- Psychiatry; Stead Family Department of Pediatrics
- Record Identifier
- 9984003941202771
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