Journal article
Obesity and Colorectal Cancer
Clinics in colon and rectal surgery, Vol.24(4), pp.229-243
12/2011
DOI: 10.1055/s-0031-1295686
PMCID: PMC3311490
PMID: 23204938
Abstract
Obesity is a risk factor for colorectal cancer based on its molecular and metabolic effects on insulin and IGF-1, leptin, adipocytokines, and sex hormones. Obese men have a higher risk of colorectal cancer compared with normal weight men, but the association between obesity and rectal cancer is weaker than with colon cancer. There is a weaker association between obesity and colon cancer in women than in men, and no appreciable association between obesity and rectal cancer in women. Although obesity does not seem to have an effect on the number of lymph nodes harvested with resection, obesity does seem to be associated with more-aggressive colorectal cancers in a handful of studies. Survival and local recurrence studies are contradictory with no conclusive evidence that obesity predisposes to worse overall survival or increased recurrence in colon and rectal cancers. The literature is not definitive as far as overall morbidity and mortality rates in the obese are concerned, though obese rectal cancer patients seem to incur proportionally more morbidity and mortality. Preexisting steatosis or steatohepatitis in obese colorectal cancer patients or chemotherapy-induced liver dysfunction may lead to an increased mortality in obese patients with colorectal liver metastases. Diabetes may cause poorer response to neoadjuvant therapy in rectal cancer and contribute to higher mortality and recurrence in colon cancer.
Details
- Title: Subtitle
- Obesity and Colorectal Cancer
- Creators
- Irena Gribovskaja-Rupp - Department of Surgery, Division of Colorectal Surgery, Medical College of Wisconsin, Milwaukee, WisconsinLauren Kosinski - Department of Surgery, Division of Colorectal Surgery, Medical College of Wisconsin, Milwaukee, WisconsinKirk A Ludwig - Department of Surgery, Division of Colorectal Surgery, Medical College of Wisconsin, Milwaukee, Wisconsin
- Resource Type
- Journal article
- Publication Details
- Clinics in colon and rectal surgery, Vol.24(4), pp.229-243
- Publisher
- Thieme Medical Publishers
- DOI
- 10.1055/s-0031-1295686
- PMID
- 23204938
- PMCID
- PMC3311490
- ISSN
- 1531-0043
- eISSN
- 1530-9681
- Language
- English
- Date published
- 12/2011
- Academic Unit
- Surgery
- Record Identifier
- 9984051726102771
Metrics
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