Journal article
Obesity and diabetes genetic variants associated with gestational weight gain
American journal of obstetrics and gynecology, Vol.203(3), pp.283.e1-283.e17
09/2010
DOI: 10.1016/j.ajog.2010.06.069
PMCID: PMC3222335
PMID: 20816152
Abstract
We sought to determine whether genetic variants associated with diabetes and obesity predict gestational weight gain. A total of 960 participants in the Pregnancy, Infection, and Nutrition cohorts were genotyped for 27 single-nucleotide polymorphisms (SNPs) associated with diabetes and obesity. Among Caucasian and African American women (n = 960), KCNQ1 risk allele carriage was directly associated with weight gain (P < .01). In Bayesian hierarchical models among Caucasian women (n = 628), we found posterior odds ratios >3 for inclusion of TCF2 and THADA SNPs in our models. Among African American women (n = 332), we found associations between risk allele carriage and weight gain for the THADA and INSIG2 SNPs. In Bayesian variable selection models, we found an interaction between the TSPAN8 risk allele and pregravid obesity, with lower weight gain among obese risk allele carriers. We found evidence that diabetes and obesity risk alleles interact with maternal pregravid body mass index to predict gestational weight gain.
Details
- Title: Subtitle
- Obesity and diabetes genetic variants associated with gestational weight gain
- Creators
- Alison M Stuebe - Department of Obstetrics and Gynecology, University of North Carolina School of Medicine, Chapel Hill, NCHelen Lyon - Children's Hospital of Boston, Harvard Medical School, Boston, MAAmy H Herring - Department of Biostatistics, Gillings School of Global Public Health, Carolina Population Center, University of North Carolina at Chapel Hill, Chapel Hill, NCJoyee Ghosh - Department of Biostatistics, Gillings School of Global Public Health, Carolina Population Center, University of North Carolina at Chapel Hill, Chapel Hill, NCAlison Wise - University of North Carolina at Chapel HillKari E North - Department of Epidemiology, Gillings School of Global Public Health, Carolina Population Center, University of North Carolina at Chapel Hill, Chapel Hill, NCAnna Maria Siega-Riz - Department of Epidemiology, Gillings School of Global Public Health, Carolina Population Center, University of North Carolina at Chapel Hill, Chapel Hill, NC
- Resource Type
- Journal article
- Publication Details
- American journal of obstetrics and gynecology, Vol.203(3), pp.283.e1-283.e17
- Publisher
- Elsevier Inc
- DOI
- 10.1016/j.ajog.2010.06.069
- PMID
- 20816152
- PMCID
- PMC3222335
- ISSN
- 0002-9378
- eISSN
- 1097-6868
- Grant note
- 5T32ES007018 / National Institute of Environmental Health Sciences DK61981; DK56350 / National Institute of Diabetes and Digestive and Kidney Diseases University of North Carolina University Research Council DK056350 / Nutrition and Obesity Research Council RR00046 / General Clinical Research Center, National Institute of Health CA109804-01 / National Cancer Institute Carolina Population Center P30 ES10126 / National Institute of Environmental Health Sciences HD28684; HD28684A; HD37584; HD39373 / Eunice Kennedy Shriver National Institute of Child Health and Human Development 5K12HD050113-04 / Women's Reproductive Health Research Career Development Center
- Language
- English
- Date published
- 09/2010
- Academic Unit
- Statistics and Actuarial Science
- Record Identifier
- 9983985958502771
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